A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

American Association for the Advancement of Science (AAAS) - Tập 336 Số 6077 - Trang 86-90 - 2012
Christian Schulz1,2, Elisa Gomez Perdiguero1,2, Laurent Chorro1,2, Heather L. Szabo‐Rogers3, Nicolas Cagnard4, Katrin Kierdorf5, Marco Prinz5, Bishan Wu6, Sten Eirik W. Jacobsen6, Jeffrey W. Pollard7, Jon Frampton8, Karen Liu3, Frédéric Geissmann1,2
1Centre for Molecular and Cellular Biology of Inflammation (CMCBI), New Hunt’s House, King's College London, Great Maze Pond, London SE1 1UL, UK.
2Peter Gorer Department of Immunobiology, King’s College London, London SE1 9RT, UK
3Department of Craniofacial Development, King's College London, London SE1 9RT, UK
4Plateforme Bioinformatique INSERM/IRNEM-IFR94, Université Paris Descartes, 149 rue de Sèvres, 75015 Paris, France.
5Department of Neuropathology, University of Freiburg, and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg, Germany.
6Haematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
7Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women’s Health, Albert Einstein College of Medicine, New York, NY 10461, USA
8College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

Tóm tắt

Macrophage Development Rewritten Macrophages provide protection against a wide variety of infections and critically shape the inflammatory environment in many tissues. These cells come in many flavors, as determined by differences in gene expression, cell surface phenotype and specific function. Schulz et al. (p. 86 , published online 22 March) investigated whether adult macrophages all share a common developmental origin. Immune cells, including most macrophages, are widely thought to arise from hematopoietic stem cells (HSCs), which require the transcription factor Myb for their development. Analysis of Myb-deficient mice revealed that a population of yolk-sac–derived, tissue-resident macrophages was able to develop and persist in adult mice in the absence of HSCs. Importantly, yolk sac–derived macrophages also contributed substantially to the tissue macrophage pool even when HSCs were present.

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American Association for the Advancement of Science (AAAS)

Tập 336 Số 6077

86-90

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