A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis

American Association for the Advancement of Science (AAAS) - Tập 299 Số 5615 - Trang 2074-2076 - 2003
Jian Xu1, Magnus Bjursell1, Jason Himrod1, Su Deng1, Lynn K. Carmichael1, Herbert C. Chiang1, Lora V. Hooper1, Jeffrey I. Gordon1
1Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110 USA

Tóm tắt

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron , a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

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Tài liệu tham khảo

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We thank C. Baublite C. Foushee S. LaBrie and D. Smoller for assistance with BAC library construction and fingerprinting; A. Salyers and N. Shoemaker for providing p5482; P. Minx H. Du S.-p. Yang J. Spieth and J. Buhler for helpful discussions; C. Rexer for assistance with PCR; and P. Falk for continued support. This work was funded by AstraZeneca and the NIH (DK30292).

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American Association for the Advancement of Science (AAAS)

Tập 299 Số 5615

2074-2076

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