A Generic Integrated Physiologically based Whole‐body Model of the Glucose‐Insulin‐Glucagon Regulatory System

CPT: Pharmacometrics and Systems Pharmacology - Tập 2 Số 8 - Trang 1-10 - 2013
Stephan Schaller1,2, Stefan Willmann2, Jörg Lippert2, Julia K. Mader3, Thomas R. Pieber3, Andreas Schuppert1,2, Thomas Eißing2
1Aachen Institute for Advanced Study in Computational Engineering Sciences, RWTH Aachen, Aachen, Germany
2Bayer Technology Services GmbH, Computational Systems Biology Leverkusen Germany
3Department of Internal Medicine, Medical University of Graz, Graz, Austria

Tóm tắt

Models of glucose metabolism are a valuable tool for fundamental and applied medical research in diabetes. Use cases range from pharmaceutical target selection to automatic blood glucose control. Standard compartmental models represent little biological detail, which hampers the integration of multiscale data and confines predictive capabilities. We developed a detailed, generic physiologically based whole‐body model of the glucose‐insulin‐glucagon regulatory system, reflecting detailed physiological properties of healthy populations and type 1 diabetes individuals expressed in the respective parameterizations. The model features a detailed representation of absorption models for oral glucose, subcutaneous insulin and glucagon, and an insulin receptor model relating pharmacokinetic properties to pharmacodynamic effects. Model development and validation is based on literature data. The quality of predictions is high and captures relevant observed inter‐ and intra‐individual variability. In the generic form, the model can be applied to the development and validation of novel diabetes treatment strategies.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e65; doi:10.1038/psp.2013.40; published online 14 August 2013

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CPT: Pharmacometrics and Systems Pharmacology

Tập 2 Số 8

1-10

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