miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Blood - Tập 124 Số 1 - Trang 84-95 - 2014
Marek Mráz1,2,3, Liguang Chen3, Laura Z. Rassenti3, Emanuela M. Ghia3, Hongying Li3, Kristen Jepsen3, Erin N. Smith3, Karen Messer3, Kelly A. Frazer3, Thomas J. Kipps3
1Central European Institute of Technology, Masaryk University, Brno, Czech Republic; and
2Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic
3University of California-San Diego, Moores Cancer Center, Department of Medicine, La Jolla, CA;

Tóm tắt

Key PointsThe most abundant miRNA in CLL, miR-150, is expressed at lower levels in cases with unfavorable clinicobiological markers and worse prognosis. miR-150 regulates expression of genes encoding proteins that modulate BCR signaling in CLL.

Từ khóa


Tài liệu tham khảo

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