Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells

Artavanis-Tsakonas, 1999, Notch signaling: cell fate control and signal integration in development, Science, 284, 770, 10.1126/science.284.5415.770

Bailey, 2007, Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins, J Cell Biochem, 102, 829, 10.1002/jcb.21509

Bartel, 2009, MicroRNAs: target recognition and regulatory functions, Cell, 136, 215, 10.1016/j.cell.2009.01.002

Bhattacharyya, 2006, Relief of microRNA-mediated translational repression in human cells subjected to stress, Cell, 125, 1111, 10.1016/j.cell.2006.04.031

Broihier, 1998, zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila, Development, 125, 655, 10.1242/dev.125.4.655

Brabletz, 2005, Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin, Cells Tissues Organs, 179, 56, 10.1159/000084509

Bracken, 2008, A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition, Cancer Res, 68, 7846, 10.1158/0008-5472.CAN-08-1942

Bray, 2006, Notch signalling: a simple pathway becomes complex, Nat Rev Mol Cell Biol, 7, 678, 10.1038/nrm2009

Burk, 2008, A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells, EMBO Rep, 9, 582, 10.1038/embor.2008.74

Bushati, 2007, microRNA functions, Annu Rev Cell Dev Biol, 23, 175, 10.1146/annurev.cellbio.23.090506.123406

Chiba, 2006, Normal and deregulated notch signaling in regulation of hematopoietic stem cells and development of leukemia, Rinsho Ketsueki, 47, 371

Christoffersen, 2007, miR-200b mediates post-transcriptional repression of ZFHX1B, RNA, 13, 1172, 10.1261/rna.586807

Diaz-Benjumea, 1995, Serrate signals through Notch to establish a wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing, Development, 121, 4215, 10.1242/dev.121.12.4215

Dominguez, 2004, Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster, Nat Genet, 36, 31, 10.1038/ng1281

Drake, 2009, ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells, Mol Biol Cell, 20, 2207, 10.1091/mbc.E08-10-1076

Ferres-Marco, 2006, Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing, Nature, 439, 430, 10.1038/nature04376

Fidler, 2003, The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited, Nat Rev Cancer, 3, 453, 10.1038/nrc1098

Gibbons, 2009, Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression, Genes Dev, 23, 2140, 10.1101/gad.1820209

Gregory, 2008, The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1, Nat Cell Biol, 10, 593, 10.1038/ncb1722

Gupta, 2006, Cancer metastasis: building a framework, Cell, 127, 679, 10.1016/j.cell.2006.11.001

Hilton, 2008, Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation, Nat Med, 14, 306, 10.1038/nm1716

Hu, 2009, A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer, Gynecol Oncol, 114, 457, 10.1016/j.ygyno.2009.05.022

Hurteau, 2007, Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin, Cancer Res, 67, 7972, 10.1158/0008-5472.CAN-07-1058

Hyun, 2009, Conserved microRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K, Cell, 139, 1096, 10.1016/j.cell.2009.11.020

Karres, 2007, The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila, Cell, 131, 136, 10.1016/j.cell.2007.09.020

Krejci, 2009, Direct response to Notch activation: signaling crosstalk and incoherent logic, Sci Signal, 2, ra1, 10.1126/scisignal.2000140

Kopan, 2009, The canonical Notch signaling pathway: unfolding the activation mechanism, Cell, 137, 216, 10.1016/j.cell.2009.03.045

Korpal, 2008, The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2, J Biol Chem, 283, 14910, 10.1074/jbc.C800074200

Leatherman, 2008, Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal, Cell Stem Cell, 3, 44, 10.1016/j.stem.2008.05.001

Lee, 2004, Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways, Cell, 117, 69, 10.1016/S0092-8674(04)00261-2

Li, 2005, A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye, Cell, 123, 1267, 10.1016/j.cell.2005.10.040

Li, 2010, Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels, Cancer Res, 70, 5226, 10.1158/0008-5472.CAN-09-4227

Liu, 2008, Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development, PLoS ONE, 3, e3592, 10.1371/journal.pone.0003592

Mani, 2008, The epithelial-mesenchymal transition generates cells with properties of stem cells, Cell, 133, 704, 10.1016/j.cell.2008.03.027

Martinez, 2009, Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling, Nat Genet, 41, 1076, 10.1038/ng.414

Miele, 2006, NOTCH signaling as a novel cancer therapeutic target, Curr Cancer Drug Targets, 6, 313, 10.2174/156800906777441771

Mitchell, 2000, Phenotypic and genotypic characterization of commonly used human prostatic cell lines, BJU Int, 85, 932, 10.1046/j.1464-410x.2000.00606.x

Mishima, 2006, Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430, Curr Biol, 16, 2135, 10.1016/j.cub.2006.08.086

Pagliarini, 2003, A genetic screen in Drosophila for metastatic behavior, Science, 302, 1227, 10.1126/science.1088474

Palomero, 2007, Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia, Nat Med, 13, 1203, 10.1038/nm1636

Pannuti, 2010, Targeting Notch to target cancer stem cells, Clin Cancer Res, 16, 3141, 10.1158/1078-0432.CCR-09-2823

Park, 2008, The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2, Genes Dev, 22, 894, 10.1101/gad.1640608

Porkka, 2007, MicroRNA expression profiling in prostate cancer, Cancer Res, 67, 6130, 10.1158/0008-5472.CAN-07-0533

Postigo, 2003, Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway, EMBO J, 22, 2443, 10.1093/emboj/cdg225

Postigo, 1999, zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesis, Mol Cell Biol, 19, 7255, 10.1128/MCB.19.10.7255

Qiao, 2009, Role of Notch signaling in colorectal cancer, Carcinogenesis, 30, 1979, 10.1093/carcin/bgp236

Rehmsmeier, 2004, Fast and effective prediction of microRNA/target duplexes, RNA, 10, 1507, 10.1261/rna.5248604

Rodilla, 2009, Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer, Proc Natl Acad Sci USA, 106, 6315, 10.1073/pnas.0813221106

Santagata, 2004, JAGGED1 expression is associated with prostate cancer metastasis and recurrence, Cancer Res, 64, 6854, 10.1158/0008-5472.CAN-04-2500

Schmalhofer, 2009, E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer, Cancer Metastasis Rev, 28, 151, 10.1007/s10555-008-9179-y

Scorey, 2006, Notch signalling and voltage-gated Na+ channel activity in human prostate cancer cells: independent modulation of in vitro motility, Prostate Cancer Prostatic Dis, 9, 399, 10.1038/sj.pcan.4500894

Shimono, 2009, Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells, Cell, 138, 592, 10.1016/j.cell.2009.07.011

Singh, 2006, Lobe and Serrate are required for cell survival during early eye development in Drosophila, Development, 133, 4771, 10.1242/dev.02686

Spaderna, 2008, The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer, Cancer Res, 68, 537, 10.1158/0008-5472.CAN-07-5682

Thiery, 2009, Epithelial-mesenchymal transitions in development and disease, Cell, 139, 871, 10.1016/j.cell.2009.11.007

Thomas, 1991, The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs, Development, 111, 749, 10.1242/dev.111.3.749

Valastyan, 2009, MicroRNAs: crucial multi-tasking components in the complex circuitry of tumor metastasis, Cell Cycle, 8, 3506, 10.4161/cc.8.21.9802

Vella, 2004, Architecture of a validated microRNA::target interaction, Chem Biol, 11, 1619, 10.1016/j.chembiol.2004.09.010

Vrba, 2010, Role of DNA methylation in the regulation of mir-200c and mir-141 expression in normal and cancer cells, PLoS One, 5, e8697, 10.1371/journal.pone.0008697

Walters, 2005, Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation, Dev Biol, 286, 415, 10.1016/j.ydbio.2005.06.031

Wang, 2010, Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways, J Cell Biochem, 109, 726, 10.1002/jcb.22451

Wang, 2011, Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells, J Cell Biochem, 112, 78, 10.1002/jcb.22770

Wellner, 2009, The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs, Nat Cell Biol, 11, 1487, 10.1038/ncb1998

Xi, 2006, Prognostic values of microRNAs in colorectal cancer, Biomark Insights, 2, 113

Zang, 2007, A study on Notch signaling in human breast cancer, Neoplasma, 54, 304

Zhang, 2006, Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells, Int J Cancer, 119, 2071, 10.1002/ijc.22077