A chromatography/tandem mass spectrometry method for the simultaneous profiling of ten endogenous steroids, including progesterone, adrenal precursors, androgens and estrogens, using low serum volume

Schioler, 1988, Six direct radioimmunoassays of estradiol evaluated, Clin. Chem., 34, 949, 10.1093/clinchem/34.5.949 Stanczyk, 2010, Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies, Cancer Epidemiol. Biomarkers Prev., 19, 903, 10.1158/1055-9965.EPI-10-0081 Taieb, 2003, Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children, Clin. Chem., 49, 1381, 10.1373/49.8.1381 Thomas, 1987, Measurement of serum estradiol: comparison of three “direct” radioimmunoassays and effects of organic solvent extraction, Clin. Chem., 33, 1946, 10.1093/clinchem/33.10.1946a Bhasin, 2010, Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline, J. Clin. Endocrinol. Metab., 95, 2536, 10.1210/jc.2009-2354 Ketha, 2014, Clinical applications of LC–MS sex steroid assays: evolution of methodologies in the 21st century, Curr. Opin. Endocrinol. Diabetes Obes., 21, 217, 10.1097/MED.0000000000000068 Giese, 2003, Measurement of endogenous estrogens: analytical challenges and recent advances, J. Chromatogr. A, 1000, 401, 10.1016/S0021-9673(03)00306-6 Cavalieri, 2010, Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancers, Future Oncol., 6, 75, 10.2217/fon.09.137 Ingle, 2015, Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole, Steroids, 99, 32, 10.1016/j.steroids.2014.08.007 Ingle, 2010, Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors, J. Clin. Oncol., 28, 4674, 10.1200/JCO.2010.28.5064 Mostaghel, 2014, Targeted androgen pathway suppression in localized prostate cancer: a pilot study, J. Clin. Oncol., 32, 229, 10.1200/JCO.2012.48.6431 Taplin, 2014, Intense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant study, J. Clin. Oncol., 32, 3705, 10.1200/JCO.2013.53.4578 Ceglarek, 2009, Rapid quantification of steroid patterns in human serum by on-line solid phase extraction combined with liquid chromatography-triple quadrupole linear ion trap mass spectrometry, Clin. Chim. Acta, 401, 114, 10.1016/j.cca.2008.11.022 Gouveia, 2013, Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: a review, Metabolism, 62, 1206, 10.1016/j.metabol.2013.04.003 Ke, 2014, A sensitive simple and robust LC–MS/MS method for the simultaneous quantification of seven androgen- and estrogen-related steroids in postmenopausal serum, J. Steroid Biochem. Mol. Biol., 144B, 523, 10.1016/j.jsbmb.2014.08.015 Keski-Rahkonen, 2011, Fast and sensitive liquid chromatography-mass spectrometry assay for seven androgenic and progestagenic steroids in human serum, J. Steroid Biochem. Mol. Biol., 127, 396, 10.1016/j.jsbmb.2011.06.006 Koal, 2012, Standardized LC–MS/MS based steroid hormone profile-analysis, J. Steroid Biochem. Mol. Biol., 129, 129, 10.1016/j.jsbmb.2011.12.001 Kulle, 2010, A novel ultrapressure liquid chromatography tandem mass spectrometry method for the simultaneous determination of androstenedione, testosterone, and dihydrotestosterone in pediatric blood samples: age- and sex-specific reference data, J. Clin. Endocrinol. Metab., 95, 2399, 10.1210/jc.2009-1670 Stanczyk, 2010, Advantages and challenges of mass spectrometry assays for steroid hormones, J. Steroid Biochem. Mol. Biol., 121, 491, 10.1016/j.jsbmb.2010.05.001 Wooding, 2015, Measurement of estradiol, estrone, and testosterone in postmenopausal human serum by isotope dilution liquid chromatography tandem mass spectrometry without derivatization, Steroids, 96, 89, 10.1016/j.steroids.2015.01.007 Ke, 2015, 4-hydroxy estrogen induces DNA damage on codon 130/131 of PTEN in endometrial carcinoma cells, Mol. Cell. Endocrinol., 400, 71, 10.1016/j.mce.2014.10.027 Parada-Bustamante, 2015, Role of 2-methoxyestradiol, an endogenous estrogen metabolite, in health and disease, Mini Rev. Med. Chem., 10.2174/1389557515666150226121052 Samavat, 2015, Estrogen metabolism and breast cancer, Cancer Lett., 356, 231, 10.1016/j.canlet.2014.04.018 Zahid, 2014, Unbalanced estrogen metabolism in ovarian cancer, Int. J. Cancer, 134, 2414, 10.1002/ijc.28565 Audet-Walsh, 2011, Profiling of endogenous estrogens, their precursors, and metabolites in endometrial cancer patients: association with risk and relationship to clinical characteristics, J. Clin. Endocrinol. Metab., 96, E330, 10.1210/jc.2010-2050 Caron, 2009, Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry, Anal. Chem., 81, 10143, 10.1021/ac9019126 Cook, 2015, Association between circulating levels of sex steroid hormones and Barrett’s esophagus in men: a case-control analysis, Clin. Gastroenterol. Hepatol., 13, 673, 10.1016/j.cgh.2014.08.027 Levesque, 2013, Molecular markers in key steroidogenic pathways, circulating steroid levels, and prostate cancer progression, Clin. Cancer Res., 19, 699, 10.1158/1078-0432.CCR-12-2812 Levesque, 2014, Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway, Clin. Cancer Res., 20, 2971, 10.1158/1078-0432.CCR-13-2567 Levesque, 2014, Importance of 5alpha-reductase gene polymorphisms on circulating and intraprostatic androgens in prostate cancer, Clin. Cancer Res., 20, 576, 10.1158/1078-0432.CCR-13-1100 Nadeau, 2011, Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer, J. Clin. Endocrinol. Metab., 96, E1550, 10.1210/jc.2011-1049 Srinivas, 2009, Dodging matrix effects in liquid chromatography tandem mass spectrometric assays–compilation of key learnings and perspectives, Biomed. Chromatogr., 23, 451, 10.1002/bmc.1152 Taylor, 2005, Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry, Clin. Biochem., 38, 328, 10.1016/j.clinbiochem.2004.11.007 Lepine, 2010, Circulating estrogens in endometrial cancer cases and their relationship with tissular expression of key estrogen biosynthesis and metabolic pathways, J. Clin. Endocrinol. Metab., 95, 2689, 10.1210/jc.2010-2648 Wang, 2014, Analysis of estrogens and androgens in postmenopausal serum and plasma by liquid chromatography-mass spectrometry, Steroids Wang, 2015, Ultrasensitive quantification of serum estrogens in postmenopausal women and older men by liquid chromatography–tandem mass spectrometry, Steroids, 96, 140, 10.1016/j.steroids.2015.01.014 Rosner, 2013, Challenges to the measurement of estradiol: an endocrine society position statement, J. Clin. Endocrinol. Metab., 98, 1376, 10.1210/jc.2012-3780 Wang, 2004, Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry, J. Clin. Endocrinol. Metab., 89, 534, 10.1210/jc.2003-031287 Buttler, 2015, Simultaneous measurement of testosterone, androstenedione and dehydroepiandrosterone (DHEA) in serum and plasma using isotope-dilution 2-dimension ultra high performance liquid-chromatography tandem mass spectrometry (ID-LC–MS/MS), Clin. Chim. Acta, 438, 157, 10.1016/j.cca.2014.08.023 Keefe, 2014, Simultaneous measurement of thirteen steroid hormones in women with polycystic ovary syndrome and control women using liquid chromatography-tandem mass spectrometry, PLoS One, 9, e93805, 10.1371/journal.pone.0093805 Martins-Junior, 2015, Profiles of steroid hormones in canine X-linked muscular dystrophy via stable isotope dilution LC–MS/MS, PLoS One, 10, e0126585, 10.1371/journal.pone.0126585 Vitku, 2015, Development and validation of LC–MS/MS method for quantification of bisphenol A and estrogens in human plasma and seminal fluid, Talanta, 140, 62, 10.1016/j.talanta.2015.03.013 Gachet, 2015, A quantitative LC–MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 976–977, 6, 10.1016/j.jchromb.2014.11.001