Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening

Molecular Therapy - Tập 27 - Trang 824-836 - 2019
Alexandra G. Orlandini von Niessen1,2, Marco A. Poleganov2, Corina Rechner2, Arianne Plaschke2, Lena M. Kranz2, Stephanie Fesser2, Mustafa Diken2,3, Martin Löwer3, Britta Vallazza2, Tim Beissert3, Valesca Bukur3, Andreas N. Kuhn2, Özlem Türeci2, Ugur Sahin1,2,3
1Department for Internal Medicine, Johannes Gutenberg University, Mainz, Germany
2BioNTech RNA Pharmaceuticals GmbH, Mainz, Germany
3TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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