Crohn’s disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes

Pugliese, 2004, Type 1 diabetes mellitus of man: genetic susceptibility and resistance, Adv. Exp. Med. Biol., 552, 170 European Consortium for IDDM Genome Studies, A genome-wide scan for type 1 diabetes susceptibility genes in Scandinavian families. Identification of new loci with evidence of interactions, Am. J. Hum. Genet. 69 (2001) 1301–1313. Cox, 2001, Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families, Am. J. Hum. Genet., 69, 820, 10.1086/323501 Becker, 1998, Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases, Proc. Natl. Acad. Sci. USA, 95, 9979, 10.1073/pnas.95.17.9979 Wandstrat, 2001, The genetics of complex autoimmune diseases: non-MHC susceptibility genes, Nat. Immunol., 2, 802, 10.1038/ni0901-802 Cavanaugh, 2001, International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16, Am. J. Hum. Genet., 68, 1165, 10.1086/320119 Hugot, 2001, Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease, Nature, 411, 599, 10.1038/35079107 Ogura, 2001, A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease, Nature, 411, 603, 10.1038/35079114 Russell, 2004, Molecular genetics of Crohn’s disease, Curr. Opin. Genet. Dev., 14, 264, 10.1016/j.gde.2004.04.004 Rahman, 2003, CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis, Am. J. Hum. Genet., 73, 677, 10.1086/378076 Kabesch, 2003, Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations, J. Allergy Clin. Immunol., 111, 813, 10.1067/mai.2003.1336 Watanabe, 2004, NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses, Nat. Immunol., 5, 800, 10.1038/ni1092 Maeda, 2005, Nod2 mutation in Crohn’s disease potentiates NF-kappaB activity and IL-1beta processing, Science, 307, 734, 10.1126/science.1103685 Rook, 2004, Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders, Springer Semin. Immunopathol., 25, 237, 10.1007/s00281-003-0148-9 Terwilliger, 1992, A haplotype-based ’haplotype relative risk’ approach to detecting allelic associations, Hum. Hered., 42, 337, 10.1159/000154096 Miceli-Richard, 2001, CARD15 mutations in Blau syndrome, Nat. Genet., 29, 19, 10.1038/ng720 Kanazawa, 2005, Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome, Blood, 105, 1195, 10.1182/blood-2004-07-2972 Ferreiros-Vidal, 2003, The three most common CARD15 mutations associated with Crohn’s disease and the chromosome 16 susceptibility locus for systemic lupus erythematosus, Rheumatology (Oxford), 42, 570, 10.1093/rheumatology/keg192 Steer, 2003, Development of rheumatoid arthritis is not associated with two polymorphisms in the Crohn’s disease gene CARD15, Rheumatology (Oxford), 42, 304, 10.1093/rheumatology/keg091 Miceli-Richard, 2002, CARD15/NOD2 analyses in spondylarthropathy, Arthritis Rheum., 46, 1405, 10.1002/art.10196 Ferreiros-Vidal, 2003, Lack of association of ankylosing spondylitis with the most common NOD2 susceptibility alleles to Crohn’s disease, J. Rheumatol., 30, 102 Sawcer, 2003, Crohn’s associated NOD2 gene variants are not involved in determining susceptibility to multiple sclerosis, J. Neurol. Neurosurg. Psychiatry, 74, 1157, 10.1136/jnnp.74.8.1157 Borgiani, 2002, Exclusion of CARD15/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population, Eur. J. Dermatol., 12, 540 Giardina, 2004, Psoriatic arthritis and CARD15 gene polymorphisms: no evidence for association in the Italian population, J. Invest. Dermatol., 122, 1106, 10.1111/j.0022-202X.2004.22524.x Lascorz, 2005, Lack of genetic association of the three more common polymorphisms of CARD15 with psoriatic arthritis and psoriasis in a German cohort, Ann. Rheum. Dis., 64, 951, 10.1136/ard.2004.029157 Hampe, 2002, Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p, Proc. Natl. Acad. Sci. USA, 99, 321, 10.1073/pnas.261567999