First-episode major depression in adolescents

British Journal of Psychiatry - Tập 176 Số 2 - Trang 142-149 - 2000
Ian Goodyer1, J. Herbert2, Andrea K. Tamplin1, P. M. E. Altham3
1Developmental Psychiatry Section, Department of Psychiatry, Cambridge Clinical School, University of Cambridge and Lifespan Healthcare Trust
2Neuroendocrine Laboratory, Department of Anatomy, University of Cambridge
3Statistical Laboratory, University of Cambridge

Tóm tắt

BackgroundThere is little information on whether patterns of steroids precede and are associated with depressive onset.AimsTo establish whether there is an association between salivary cortisol and/or dihydroepiandrosterone (DHEA) levels and depression independent of psychosocial risk.MethodTwo subgroups of adolescents in the community at high (n=181) and low (n=65) risk for psychopathology were interviewed for recent psychiatric disorder at entry and again at 12 months. Salivary samples (08.00 and 20.00 h) for hormone estimations and self-reports on current mood and cognitive style were obtained at both assessments.ResultsNeither hormone was associated with risk status, current mood or cognitive style at entry. Of 31 onsets of major depression that occurred over the next 12 months, 30 came from the high-risk group but were not associated with any particular pattern of risk. Increased negative mood and feelings and DHEA (08.00 h) hypersecretion at entry were associated with subsequent major depression.ConclusionsBoth negative mood and feelings and alterations in adrenal steroid function precede the onset of first-episode major depression in adolescents. Variation in levels of hormones may arise from more distal origins than recent life events and current ongoing difficulties.

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Thông tin
Thông tin xuất bản

British Journal of Psychiatry

Tập 176 Số 2

142-149

Thông tin tác giả