First-episode major depression in adolescents
Tóm tắt
There is little information on whether patterns of steroids precede and are associated with depressive onset.
To establish whether there is an association between salivary cortisol and/or dihydroepiandrosterone (DHEA) levels and depression independent of psychosocial risk.
Two subgroups of adolescents in the community at high (
Neither hormone was associated with risk status, current mood or cognitive style at entry. Of 31 onsets of major depression that occurred over the next 12 months, 30 came from the high-risk group but were not associated with any particular pattern of risk. Increased negative mood and feelings and DHEA (08.00 h) hypersecretion at entry were associated with subsequent major depression.
Both negative mood and feelings and alterations in adrenal steroid function precede the onset of first-episode major depression in adolescents. Variation in levels of hormones may arise from more distal origins than recent life events and current ongoing difficulties.
Từ khóa
Tài liệu tham khảo
Ingram, 1998, Cognitive Vulnerability to Depression
Wamboldt, 1990, The Reliability and Validity of the EAS Scales
Reynolds, 1983, National normative and reliability data for the revised Children's Manifest Anxiety Scale, School Psychology Review, 12, 324, 10.1080/02796015.1983.12085047
Buss, 1984, Temperament: Early Developing Personality Traits
Brooks-Gunn, 1995, The Depressed Child and Adolescent: Developmental and Clinical Perspectives, 81
1994, Diagnostic and Statistical Manual of Mental Disorders
Brooks-Gunn, 1991, Adolescent Stress: Causes and Consequences, 131
Rutter, 1994, Risk and Resilience in Children and Adolescence, 354
Guazzo, 1996, Cortisol, dehydroepianodrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age, Journal of Clinical Endocrinology and Metabolism, 81, 3951
Goodyer, 1995, The Depressed Child and Adolescent: Developmental and Clinical Perspectives, 171
Tanner, 1978, Foetus into Man