Wound Healing--Aiming for Perfect Skin Regeneration

American Association for the Advancement of Science (AAAS) - Tập 276 Số 5309 - Trang 75-81 - 1997
Paul Martin1
1Department of Anatomy and Developmental Biology and Division of Plastic and Reconstructive Surgery, Department of Surgery, University College London, Gower Street, London WC1E 6BT, UK.

Tóm tắt

The healing of an adult skin wound is a complex process requiring the collaborative efforts of many different tissues and cell lineages. The behavior of each of the contributing cell types during the phases of proliferation, migration, matrix synthesis, and contraction, as well as the growth factor and matrix signals present at a wound site, are now roughly understood. Details of how these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.

Từ khóa


Tài liệu tham khảo

Clark R. A. F. in (1) pp. 3–50.

Riches D. W. H. in (1) pp. 95–141.

10.1016/0092-8674(94)90337-9

Mayadas T. N., et al., ibid.74, 541 (1993).

Hubner G., et al., Cytokine8, 548 (1996).

Leibovich S. J., Ross R., Am. J. Pathol.78, 71 (1975).

Cavani A., et al., J. Invest. Dermatol.101, 600 (1993);

Breuss J. M., et al., J. Cell Sci.108, 2241 (1995);

Yamada K. M. Clark R. A. F. in (1) pp. 51–93;

Haapasalmi K., et al., J. Invest. Dermatol.106, 42 (1996).

Mitcheson T. J., Cramer L. P., Cell84, 371 (1996).

Grinnell F., J. Cell. Sci.101, 1 (1992).

Garlick J. A., Taichman L. B., Lab. Invest.70, 916 (1994)

Hertle M. D., Kubler M.-D., Leigh I. M., Watt F. M., J. Clin. Invest.89, 1892 (1992).

Matoltsy A. G., Viziam C. B., J. Invest. Dermatol.55, 20 (1970);

Krawczyk W. S., J. Cell Biol.49, 247 (1971).

Compton C. C., et al., Lab. Invest.60, 600 (1989).

Rochat A., Kobayashi K., Barrandon Y., Cell76, 1063 (1994).

Jones P. H., Watt F. M., ibid.73, 713 (1993);

Jones P. H., Harper S., Watt F. M., ibid.80, 83 (1995).

Grondahl-Hansen J., et al., J. Invest. Dermatol.90, 790 (1988);

Romer J., et al., ibid97, 803 (1991);

Romer J., et al., ibid.102, 519 (1994).

Romer J., et al., Nature Med.2, 287 (1996).

Salo T., et al., Lab. Invest.70, 176. (1994).

Saarialho-Kere U. K., Chang E. S., Welgus H. G., Parks W. C., J. Clin. Invest.90, 1952 (1992).

Saarialho-Kere U. K., et al., ibid.94, 79 (1994).

Grinnell F., Ho C.-H., Wysocki A., J. Invest. Dermatol.98, 410 (1992);

Tarnuzzer R.W., Schultz G. S., Wound Repair Regen.4,321 (1996);

Mast B. A., Schultz G. S., ibid., p. 411.

Gipson I. K., Spurr-Michaud S. J., Tisdale A. S., Dev. Biol.126, 253 (1988);

Uitto J. Mauviel A. McGrath J. in (1) pp. 513–560.

Brown G. L., et al., J. Exp. Med.163, 1319 (1986);

Schultz G. S., et al., Science235, 350 (1987).

Barrandon Y., Green H., Cell50, 1131 (1987).

Ridley A. J., Hall A., ibid.70, 389 (1992);

Ridley A. J., Comoglio P. M., Hall A., Mol. Cell. Biol.15, 1110 (1995);

10.1016/0092-8674(95)90370-4

Werner S., et al., Proc. Natl. Acad. Sci. U.S.A.89, 6896 (1992).

Brauchle M., Fassler R., Werner S., J. Invest. Dermatol.105, 579 (1995).

Guo L., Degenstein L., Fuchs E., Genes Dev.10, 165 (1996).

Werner S., et al., Science266, 819 (1994).

Staiano-Coico L., et al., J. Exp. Med.178, 865 (1993);

Pierce G. F., et al., ibid.179, 831 (1994).

Tsuboi R., et al., J. Invest. Dermatol.101, 49 (1993);

Madlener M., et al., Biochem. J.320, 659 (1996).

Gailet J., Welch M. P., Clark R. A. F., J. Invest. Dermatol.103, 221 (1994);

Hertle M. D., et al., ibid.104, 260 (1995).

Martin P., Lewis J., Nature360, 179 (1992);

McCluskey J., Martin P., Dev. Biol.170, 102 (1995).

Brock J., Midwinter K., Lewis J., Martin P., J. Cell Biol.135, 1097 (1996).

Bement W. M., Forscher P., Mooseker M. S., ibid.121, 565 (1993);

Heath J. P., Cell Biol. Int.20, 139 (1996).

Guo L., et al., Cell81, 233 (1995).

Paladini R. D., Takahashi K., Bravo N. S., Coulombe P. A., J. Cell Biol.132, 381 (1996).

Brock J., McCluskey J., Baribault H., Martin P., Cell Motil. Cytoskel.35, 358 (1996).

Sengel P., in Biology of the Integument, , Bereiter-Hahn J., Matolsty A. G., Richards K. S., Eds. (Springer-Verlag, Berlin, 1986).

Zhou P., Byrne C., Jacobs J., Fuchs E., Genes Dev.9, 570 (1995);

Nohno T., et al., Biochem. Biophys. Res. Commun.206, 33 (1995);

Stenn R. S., et al.Dermatol. Clin.14, 543 (1996)] have a table of all genes expressed in developing hair bud.

Luetteke N. C., et al., Cell73, 263 (1993);

Mann G. B., et al., ibid., p. 249;

Hebert J. M., et al., ibid.78, 1017 (1994).

Jahoda C. A. B., Development115, 1103 (1992).

Eckes B. Aumailley M. Krieg T. in (1) pp. 493-512.

McClain S. A., et al., Am. J. Pathol.149, 1257 (1996).

Eriksson A., et al., EMBO J.11, 543 (1992);

Heldin C.-H. Westermark B. in (1) pp. 249–273.

Roberts A. B. Sporn M. B. in (1) pp. 275–308;

Frank S., Madlener M., Werner S., J. Biol. Chem.271, 10188 (1996).

Hubner G., Hu Q., Smola H., Werner S., Dev. Biol.173, 490 (1996).

Igarashi A., Okochi H., Bradham D. M., Grotendorst G. R., Mol. Biol. Cell4, 637 (1993);

Mason E. D., Conrad K. D., Webb C. D., Marsh J. L., Genes Dev.8, 1489 (1994);

Grotendorst G. R., Okochi H., Hayashi N., Cell Growth Differ. 7, 469 (1996);

Kothapalli D., et al., ibid.8, 61 (1997).

Xu J., Clark R. A. F., J. Cell Biol.132, 239 (1996).

Greiling D., Clark R. A. F., J. Cell Sci., in press.

Ffrench-Constant C., van de Water L., Dvorak H. F., Hynes R. O., J. Cell Biol.109, 903 (1989);

Brown L. F., et al., Am. J. Pathol.142, 793 (1993).

Witke W., et al., Cell81, 41 (1995); see S. O'Kane et al. [Mol. Biol. Cell (suppl. 7), 543a (1996)] for preliminary in vivo wound healing report.

Hartwig J. H. H., et al., Cell82, 643 (1995).

Desmouliere A. Gabbiani G. in (1) pp. 391–423.

Desmouliere A., Geinoz A., Gabbiani F., Gabbiani G., J. Cell Biol.122, 103 (1993).

Grinnell F., ibid.124, 401 (1994).

Montesano R., Orci L., Proc. Natl. Acad. Sci. U.S.A.85, 4894 (1988);

Clark R. A. F., et al., J. Clin. Invest.84, 1036 (1989).

He Y., Grinnell F., J. Cell Biol.126, 457 (1994); ibid.130, 1197 (1995).

Lin Y.-C., Grinnell F., ibid.122, 663 (1993).

Desmouliere A., Redard M., Darby I., Gabbiani G., Am. J. Pathol.146, 56 (1995).

Abraham J. A. Klagsbrun M. in (1) pp. 195–248.

Broadley K. N., et al., Lab. Invest.61, 571 (1989).

Brown L. F., et al., J. Exp. Med.176, 1375 (1992);

Berse B., et al., Mol. Biol. Cell3, 211 (1992).

Frank S., et al., J. Biol. Chem.270, 12607 (1995).

10.1126/science.7512751

Clark R. A. F., Tonnesen M. G., Gailit J., Cheresh D. A., Am. J. Pathol.148, 1407 (1996).

Fisher C., et al., Dev. Biol.162, 499 (1994).

Reynolds M. L., Fitzgerald M., J. Comp. Neurol.358, 487 (1995).

10.1097/00001756-199411000-00019

Buchman V. L., Sporn M., Davies A. M., Development120, 1621 (1994).

Mullen L. M., et al., ibid.122, 3487 (1996).

Nilsson J., von Euler A., Dalsgaard C.-J., Nature315, 61 (1985).

10.1016/0092-8674(92)90286-L

Estes J. M., et al., Differentiation56, 173 (1994).

See chapters in N. S. Adzick and M. T. Longaker Eds. Fetal Wound Healing (Elsevier New York 1992);

McCallion R. L. Ferguson M. W. J. in (1) pp. 561–600;

Martin P., Curr. Top. Dev. Biol.32, 175 (1996);

Nodder S., Martin P., Anat. Embryol.195, 215 (1997).

Longaker M. T., et al., Surg. Forum41, 639 (1990).

Armstrong J. R., Ferguson M. W. J., Dev. Biol.169, 242 (1995).

Adzick N. S., et al., J. Pediatr. Surg.20, 315 (1985);

Whitby D. J., Ferguson M. W. J., Development112, 651 (1991);

Hopkinson-Woolley J., Hughes D., Gordon S., Martin P., J. Cell Sci.107, 1159 (1994).

Whitby D. J., Ferguson M. W. J., Dev. Biol.147, 207 (1991);

Martin P., Dickson M. C., Millan F. A., Akhurst R. J., Dev. Genet.14, 225 (1993).

Noble W. A., Noble N. A., N. Engl. J. Med.331, 1286 (1994).

Shah M., Foreman D. M., Ferguson M. W. J., Lancet339, 213 (1992); J. Cell Sci.107, 1137 (1994).

Shah M., Foreman D. M., J. Cell Sci.108, 985 (1995).

McCallion R. L., Wood J. M., Foreman D. M., Ferguson M. W. J., Lancet, in press.

Verrier B., Muller D., Bravo R., Muller R., EMBO. J.5, 913 (1986);

Martin P., Nobes C. D., Mech. Dev.38, 209 (1992);

Pawar S., Kartha S., Toback F. G., J. Cell. Physiol.165, 556 (1995).

Goliger J. A., Paul D. L., Mol. Biol. Cell6, 1491 (1995).

Burgess L. P. A., et al., Arch. Otolaryngol. Head Neck Surg.116, 798 (1990).

Frank S., Munz B., Werner S., Oncogene, in press.

Nanney L. B. King L. E. in (1) pp. 171–194.

10.1126/science.3041594

Marikovsky M., et al., Proc. Natl. Acad. Sci. U.S.A.90, 3889 (1993).

Mueller R. V., Hunt T. K., Tokunaga A., Spencer E. M., Arch. Surg.129, 262 (1994).

Forsberg E., et al., Proc. Natl. Acad. Sci. U.S.A.93, 6594 (1996).