Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms

Blood - Tập 127 - Trang 1307-1316 - 2016
Marito Araki1, Yinjie Yang2, Nami Masubuchi2,3, Yumi Hironaka2, Hiraku Takei2, Soji Morishita1, Yoshihisa Mizukami2,4, Shin Kan2,5, Shuichi Shirane2, Yoko Edahiro2, Yoshitaka Sunami2, Akimichi Ohsaka1, Norio Komatsu2
1Department of Transfusion Medicine and Stem Cell Regulation
2Department of Hematology
3Research Institute for Disease of Old Age
4Center for Genomic and Regenerative Medicine
5Leading Center for the Development and Research of Cancer Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Tóm tắt

Key Points Mutant CALR induces TPO-independent growth in the human megakaryocytic cell line UT-7/TPO. Mutant CALR binds to the TPO receptor, inducing phosphorylation of JAK2 and activating downstream signaling.

Tài liệu tham khảo

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