Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy

Nature Communications - Tập 7 Số 1
Jundong Shao1, Hanhan Xie1, Hao Huang1, Zhibin Li1, Zhengbo Sun2, Yanhua Xu2, Quanlan Xiao2, Xue‐Feng Yu1, Yuetao Zhao1, Han Zhang2, Huaiyu Wang1, Paul K. Chu3
1Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
2SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
3Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, 999077, Hong Kong, China

Tóm tắt

Abstract

Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns such as the biodegradability as well as long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed by an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates the interior BPQDs from oxygen and water to enhance the photothermal stability, but also control the degradation rate of the BPQDs. The in vitro and in vivo experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good biocompatibility, and possess excellent PTT efficiency and tumour targeting ability as evidenced by highly efficient tumour ablation under near infrared (NIR) laser illumination. These BP-based nanospheres combine biodegradability and biocompatibility with high PTT efficiency, thus promising high clinical potential.

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