Structured form of DHA prevents neurodegenerative disorders: A better insight into the pathophysiology and the mechanism of DHA transport to the brain
Tóm tắt
Từ khóa
Tài liệu tham khảo
Balić, 2020, Omega-3 versus omega-6 polyunsaturated fatty acids in the prevention and treatment of inflammatory skin diseases, Int J Mol Sci, 21, 741, 10.3390/ijms21030741
Zárate, 2017, Significance of long chain polyunsaturated fatty acids in human health, Clin Transl Med, 6, 25, 10.1186/s40169-017-0153-6
Balakrishnan, 2019, Omega‐3‐rich Isochrysis sp. biomass enhances brain docosahexaenoic acid levels and improves serum lipid profile and antioxidant status in Wistar rats, J Sci Food Agric, 99, 6066, 10.1002/jsfa.9884
Ryckebosch, 2014, Nutritional evaluation of microalgae oils rich in omega-3 long chain polyunsaturated fatty acids as an alternative for fish oil, Food Chem, 160, 393, 10.1016/j.foodchem.2014.03.087
Kerdiles, 2017, Omega-3 polyunsaturated fatty acids and brain health: preclinical evidence for the prevention of neurodegenerative diseases, Trends Food Sci Technol, 69, 203, 10.1016/j.tifs.2017.09.003
Domenichiello, 2015, Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?, Prog Lipid Res, 59, 54, 10.1016/j.plipres.2015.04.002
Brenna, 2014, Docosahexaenoic acid and human brain development: evidence that a dietary supply is needed for optimal development, J Hum Evol, 77, 99, 10.1016/j.jhevol.2014.02.017
Sugasini, 2017, Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice, Sci Rep, 7, 1, 10.1038/s41598-017-11766-0
Albert, 2015, Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA, Sci Rep, 5, 7928, 10.1038/srep07928
Bradbury, 2011, Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain, Nutrients, 5, 529, 10.3390/nu3050529
Farooqui, 2000, Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders, Chem Phys Lipids, 106, 1, 10.1016/S0009-3084(00)00128-6
Fialkow, 2016, Omega-3 fatty acid formulations in cardiovascular disease: dietary supplements are not substitutes for prescription products, Am J Cardiovasc Drugs, 16, 229, 10.1007/s40256-016-0170-7
Youdim, 2000, Essential fatty acids and the brain: possible health implications, Int J Dev Neurosci, 18, 383, 10.1016/S0736-5748(00)00013-7
Innis, 2007, Human milk: maternal dietary lipids and infant development, Proc Nutr Soc, 66, 397, 10.1017/S0029665107005666
Daiello, 2015, Alzheimer's Disease Neuroimaging Initiative. Association of fish oil supplement use with preservation of brain volume and cognitive function, Alzheimer's Dementia, 11, 226, 10.1016/j.jalz.2014.02.005
Skorve, 2015, Fish oil and krill oil differentially modify the liver and brain lipidome when fed to mice, Lipid Health Dis, 14, 88, 10.1186/s12944-015-0086-2
Kagan, 2015, Comparative study of tissue deposition of omega-3 fatty acids from polar-lipid rich oil of the microalgae Nannochloropsis oculata with krill oil in rats, Food Func, 6, 185, 10.1039/C4FO00591K
Simopoulos, 1999, New products from the agri‐food industry: the return of n‐3 fatty acids into the food supply, Lipids, 34, S297, 10.1007/BF02562324
Simopoulos, 2011, Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain, Mol Neurobiol, 44, 203, 10.1007/s12035-010-8162-0
Kastel, 2007, The effect of probiotics potentiated with polyunsaturated fatty acids on the digestive tract of germ-free piglets, Veterinarni Medicina-Praha-, 52, 63, 10.17221/2055-VETMED
Petroni, 1998, The β-oxidation of arachidonic acid and the synthesis of docosahexaenoic acid are selectively and consistently altered in skin fibroblasts from three Zellweger patients versus X-adrenoleukodystrophy, Alzheimer and control subjects, Neurosci Lett, 250, 145, 10.1016/S0304-3940(98)00467-4
Voss, 1991, The metabolism of 7, 10, 13, 16, 19-docosapentaenoic acid to 4, 7, 10, 13, 16, 19-docosahexaenoic acid in rat liver is independent of a 4-desaturase, J Biol Chem, 266, 19995, 10.1016/S0021-9258(18)54882-1
Metherel, 2016, Whole-body DHA synthesis-secretion kinetics from plasma eicosapentaenoic acid and alpha-linolenic acid in the free-living rat, Biochimica et Biophysica Acta (BBA)-Mol Cell Biol Lipids, 1861, 997, 10.1016/j.bbalip.2016.05.014
Metherel, 2017, Retroconversion is a minor contributor to increases in eicosapentaenoic acid following docosahexaenoic acid feeding as determined by compound specific isotope analysis in rat liver, Nutr Metab, 14, 1, 10.1186/s12986-017-0230-2
Metherel, 2019, Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat, J Lipid Res, 60, 412, 10.1194/jlr.M090373
Loguercio, 2001, Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects, J Hepatol, 35, 568, 10.1016/S0168-8278(01)00192-1
Valenzuela, 2011, The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity, Food Funct, 2, 644, 10.1039/c1fo10133a
Sies, 2005, Nutritional, dietary and postprandial oxidative stress, J Nutr, 135, 969, 10.1093/jn/135.5.969
Houstis, 2006, Reactive oxygen species have a causal role in multiple forms of insulin resistance, Nature, 440, 944, 10.1038/nature04634
Nakamura, 2004, Structure, function, and dietary regulation of Δ6, Δ5, and Δ9 desaturases, Annu Rev Nutr, 24, 345, 10.1146/annurev.nutr.24.121803.063211
Simopoulos, 2009, Omega-6/omega-3 essential fatty acids: biological effects, World Rev Nutr Diet, 99, 1
van Vliet, 1990, Lower ratio of n-3 to n-6 fatty acids in cultured than in wild fish, Am J Clin Nutr, 51, 1, 10.1093/ajcn/51.1.1
Farrell, 2006, Nonalcoholic fatty liver disease: from steatosis to cirrhosis, Hepatology, 43, S99, 10.1002/hep.20973
Fabbrini, 2008, Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease, Gastroenterology, 134, 424, 10.1053/j.gastro.2007.11.038
Aronis, 2005, Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774. 2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis, Free Radic Biol Med, 38, 1221, 10.1016/j.freeradbiomed.2005.01.015
Videla, 2006, Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease, Trends Mol Med, 12, 555, 10.1016/j.molmed.2006.10.001
Salem, 2001, Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids, J Mol Neurosci, 16, 299, 10.1385/JMN:16:2-3:299
Wainwright, 2002, Dietary essential fatty acids and brain function: a developmental perspective on mechanisms, Proc Nutr Soc, 61, 61, 10.1079/PNS2001130
Al, 2000, Long-chain polyunsaturated fatty acids, pregnancy, and pregnancy outcome, Am J Clin Nutr, 71, 285, 10.1093/ajcn/71.1.285s
Alessandri, 2004, Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life, Reprod Nutr Dev, 44, 509, 10.1051/rnd:2004063
Antalis, 2006, Omega-3 fatty acid status in attention-deficit/hyperactivity disorder, Prostaglandins Leukot Essent Fatty Acids, 75, 299, 10.1016/j.plefa.2006.07.004
Sinn, 2008, Cognitive effects of polyunsaturated fatty acids in children with attention deficit hyperactivity disorder symptoms: a randomised controlled trial, Prostaglandins Leukot Essent Fatty Acids, 78, 311, 10.1016/j.plefa.2008.04.004
Richardson, 2002, A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties, Prog Neuropsychopharmacol Biol Psychiatry, 26, 233, 10.1016/S0278-5846(01)00254-8
McNamara, 2009, Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects, J Psychiatr Res, 43, 656, 10.1016/j.jpsychires.2008.09.011
Simopoulos, 1999, Essential fatty acids in health and chronic disease, Am J Clin Nutr, 70, 560s, 10.1093/ajcn/70.3.560s
Pettinelli, 2009, Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion, Biochimica Et Biophysica Acta (BBA)-Mol Basis Dis, 1792, 1080, 10.1016/j.bbadis.2009.08.015
Araya, 2004, Increase in long-chain polyunsaturated fatty acid n− 6/n− 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease, Clin Sci, 106, 635, 10.1042/CS20030326
Fernández, 2012, Recent advances in liver preconditioning: thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron, World J Hepatol, 4, 119, 10.4254/wjh.v4.i4.119
Georgiadi, 2012, Mechanisms of gene regulation by fatty acids, Adv Nutr, 3, 127, 10.3945/an.111.001602
Tugwood, 1992, The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene, EMBO J, 11, 433, 10.1002/j.1460-2075.1992.tb05072.x
Nakatani, 2003, A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver relationship to anti-obesity, J Lipid Res, 44, 369, 10.1194/jlr.M200289-JLR200
Sampath, 2005, Polyunsaturated fatty acid regulation of genes of lipid metabolism, Annu Rev Nutr, 25, 317, 10.1146/annurev.nutr.25.051804.101917
Krey, 1997, Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay, Mol Endocrinol, 11, 779, 10.1210/mend.11.6.0007
Sen, 1996, Antioxidant and redox regulation of gene transcription, FASEB J, 10, 709, 10.1096/fasebj.10.7.8635688
Iemitsu, 2002, Aging-induced decrease in the PPAR-α level in hearts is improved by exercise training, Am J Physiol-Heart Circ Physiol, 283, 1750, 10.1152/ajpheart.01051.2001
Sanguino, 2005, Atorvastatin reverses age‐related reduction in rat hepatic PPARα and HNF‐4, Br J Pharmacol, 145, 853, 10.1038/sj.bjp.0706260
Atherton, 2009, Metabolomics of the interaction between PPAR‐α and age in the PPAR‐α‐null mouse, Mol Syst Biol, 5, 259, 10.1038/msb.2009.18
Zolezzi, 2013, Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?, PLoS One, 8, 64019, 10.1371/journal.pone.0064019
Pérez-Martín, 2016, Environmental enrichment, age, and PPARα interact to regulate proliferation in neurogenic niches, Front Neurosci, 10, 89, 10.3389/fnins.2016.00089
Jiang, 2007, Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells, PLoS One, 2, 641, 10.1371/journal.pone.0000641
Rashid, 2013, N‐docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation, J Neurochem, 125, 869, 10.1111/jnc.12255
Kim, 2011, A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development, Prostaglandins Other Lipid Mediat, 96, 114, 10.1016/j.prostaglandins.2011.07.002
Rossmeisl, 2012, Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids, PLoS One, 7, e38834, 10.1371/journal.pone.0038834
Kim, 2016, Dietary DHA reduces downstream endocannabinoid and inflammatory gene expression and epididymal fat mass while improving aspects of glucose use in muscle in C57BL/6J mice, Int J Obes (Lond), 40, 129, 10.1038/ijo.2015.135
Buczynski, 2010, Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord, J Neurochem, 114, 981, 10.1111/j.1471-4159.2010.06815.x
Gould, 1999, Learning enhances adult neurogenesis in the hippocampal formation, Nat Neurosci, 2, 260, 10.1038/6365
Fuentealba, 2015, Embryonic origin of postnatal neural stem cells, Cell, 161, 1644, 10.1016/j.cell.2015.05.041
Kempermann, 2002, Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment, Ann Neurol, 52, 135, 10.1002/ana.10262
Clelland, 2009, A functional role for adult hippocampal neurogenesis in spatial pattern separation, Science, 325, 210, 10.1126/science.1173215
Jessberger, 2009, Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats, Learn Memory, 16, 147, 10.1101/lm.1172609
Kharebava, 2015, N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons, Biol Open, 4, 1660, 10.1242/bio.013425
Bezuglov, 2001, Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine, Bioorg Med Chem Lett, 11, 447, 10.1016/S0960-894X(00)00689-2
Bobrov, 2006, Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine, Bull Exp Biol Med, 142, 425, 10.1007/s10517-006-0383-x
Devassy, 2016, Omega-3 polyunsaturated fatty acids and oxylipins in neuroinflammation and management of Alzheimer disease, Adv Nutr, 7, 905, 10.3945/an.116.012187
Wang, 2017, N-Docosahexaenoyl dopamine, an endocannabinoid-like conjugate of dopamine and the n-3 fatty acid docosahexaenoic acid, attenuates lipopolysaccharide-induced activation of microglia and macrophages via COX-2, ACS Chem Neurosci, 8, 548, 10.1021/acschemneuro.6b00298
Wang, 2019, Phospholipid remodeling in physiology and disease, Annu Rev Physiol, 81, 165, 10.1146/annurev-physiol-020518-114444
Ramırez, 2001, Absorption and distribution of dietary fatty acids from different sources, Early Hum Dev, 65, S95, 10.1016/S0378-3782(01)00211-0
Wong, 2016, Mfsd2a is a transporter for the essential ω-3 fatty acid docosahexaenoic acid (DHA) in eye and is important for photoreceptor cell development, J Biol Chem, 291, 10501, 10.1074/jbc.M116.721340
Polette, 1999, Synthesis of acetyl, docosahexaenoyl-glycerophosphocholine and its characterization using nuclear magnetic resonance, Lipids, 34, 1333, 10.1007/s11745-999-0486-1
Galli, 1992, Prolonged retention of doubly labeled phosphatidylcholine in human plasma and erythrocytes after oral administration, Lipids, 27, 1005, 10.1007/BF02535580
Arnesjö, 1969, Intestinal digestion and absorption of cholesterol and lecithin in the human: intubation studies with a fat-soluble reference substance, Scand J Gastroenterol, 4, 653, 10.3109/00365526909180651
Dac, 1976, Intestinal absorption of polyunsaturated phosphatidylcholine in the rat, Hoppe-Seyler´ s Zeitschrift für physiologische Chemie, 357, 1321, 10.1515/bchm2.1976.357.2.1321
Van, 2016, Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases, Biochimie, 130, 163, 10.1016/j.biochi.2016.07.011
Nguyen, 2014, Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid, Nature, 509, 503, 10.1038/nature13241
Chen, 2015, Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain, Sci Rep, 5, 15791, 10.1038/srep15791
Chen, 2008, Regulation of brain polyunsaturated fatty acid uptake and turnover, Prostaglandins Leukot Essent Fatty Acids, 79, 85, 10.1016/j.plefa.2008.09.003
Bazinet, 2019, How the plasma lysophospholipid and unesterified fatty acid pools supply the brain with docosahexaenoic acid, Prostaglandins Leukot Essent Fatty Acids, 142, 1, 10.1016/j.plefa.2018.12.003
Zhao, 2014, Blood-brain barrier: a dual life of MFSD2A?, Neuron, 82, 728, 10.1016/j.neuron.2014.05.012
Sandoval, 2008, Fatty acid transport and activation and the expression patterns of genes involved in fatty acid trafficking, Arch Biochem Biophys, 477, 363, 10.1016/j.abb.2008.06.010
Bazinet, 2014, Polyunsaturated fatty acids and their metabolites in brain function and disease, Nat Rev Neurosci, 15, 771, 10.1038/nrn3820
Lacombe, 2018, Brain docosahexaenoic acid uptake and metabolism, Mol Aspects Med, 64, 109, 10.1016/j.mam.2017.12.004
Pan, 2016, Fatty acid-binding protein 5 at the blood–brain barrier regulates endogenous brain docosahexaenoic acid levels and cognitive function, J Neurosci, 36, 11755, 10.1523/JNEUROSCI.1583-16.2016
Lee, 2018, Fatty acid–binding protein 5 mediates the uptake of fatty acids, but not drugs, into human brain endothelial cells, J Pharm Sci, 107, 1185, 10.1016/j.xphs.2017.11.024
Ben-Zvi, 2014, Mfsd2a is critical for the formation and function of the blood–brain barrier, Nature, 509, 507, 10.1038/nature13324
Guemez-Gamboa, 2015, Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome, Nat Genet, 47, 809, 10.1038/ng.3311
Alakbarzade, 2015, A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome, Nat Genet, 47, 814, 10.1038/ng.3313
Hachem, 2016, Efficient docosahexaenoic acid uptake by the brain from a structured phospholipid, Mol Neurobiol, 53, 3205, 10.1007/s12035-015-9228-9
Bernoud-Hubac, 2017, Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC. OCL - Oilseeds fats, Crop. Lipids, 24, 1
Thies, 1994, Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain, Am J Physiol, 1, R1273
Bernoud, 1999, Preferential transfer of 2‐docosahexaenoyl‐1‐lysophosphatidylcholine through an in vitro blood‐brain barrier over unesterified docosahexaenoic acid, J Neurochem, 72, 338, 10.1046/j.1471-4159.1999.0720338.x
Polozova, 2007, Role of liver and plasma lipoproteins in selective transport of n-3 fatty acids to tissues: a comparative study of 14 C-DHA and 3 H-oleic acid tracers, J Mol Neurosci, 33, 56, 10.1007/s12031-007-0039-y
Valenzuela, 2010, Supplementing female rats with DHA-lysophosphatidylcholine increases docosahexaenoic acid and acetylcholine contents in the brain and improves the memory and learning capabilities of the pups, Grasas Aceites, 10.3989/gya.053709
Sugasini, 2017, Curcumin and linseed oil co-delivered in phospholipid nanoemulsions enhances the levels of docosahexaenoic acid in serum and tissue lipids of rats, Prostaglandins Leukot Essent Fatty Acids, 119, 45, 10.1016/j.plefa.2017.03.007
Yalagala, 2019, Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: potential treatment for depression, J Lipid Res, 60, 566, 10.1194/jlr.M090464
Croset, 1996, In vivo compartmental metabolism of13C docosahexaenoic acid, studied by gas chromatography‐combustion isotope ratio mass spectrometry, Lipids, 31, 109, 10.1007/BF02637061
Chen, 2007, Phospholipid and fatty acid specificity of endothelial lipase: potential role of the enzyme in the delivery of docosahexaenoic acid (DHA) to tissues, Biochimica et Biophysica Acta (BBA)-Mol Cell Biol Lipids, 1771, 1319, 10.1016/j.bbalip.2007.08.001
Wu, 2017, Comparative analyses of DHA-phosphatidylcholine and recombination of DHA-triglyceride with egg-phosphatidylcholine or glycerylphosphorylcholine on DHA repletion in n-3 deficient mice, Lipids Health Dis, 16, 234, 10.1186/s12944-017-0623-2
Kitson, 2016, Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion, J Nutr Biochem, 33, 91, 10.1016/j.jnutbio.2016.02.009
Chouinard‐Watkins, 2019, DHA esterified to phosphatidylserine or phosphatidylcholine is more efficient at targeting the brain than DHA esterified to triacylglycerol, Mol Nutr Food Res, 63, 10.1002/mnfr.201801224
Bredesen, 2016, Reversal of cognitive decline in Alzheimer's disease, Aging (Albany NY), 8, 1250, 10.18632/aging.100981
Lim, 2013, Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep, JAMA Neurol, 70, 1544, 10.1001/jamaneurol.2013.4215
Smith, 2014, Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease, Front Aging Neurosci, 6, 61, 10.3389/fnagi.2014.00061
Freund Levi, 2014, Transfer of omega‐3 fatty acids across the blood–brain barrier after dietary supplementation with a docosahexaenoic acid‐rich omega‐3 fatty acid preparation in patients with Alzheimer's disease: the Omega AD study, J Intern Med, 275, 428, 10.1111/joim.12166
Pifferi, 2005, (n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats, J Nutr, 135, 2241, 10.1093/jn/135.9.2241
Ximenes da Silva, 2002, Glucose transport and utilization are altered in the brain of rats deficient in n‐3 polyunsaturated fatty acids, J Neurochem, 81, 1328, 10.1046/j.1471-4159.2002.00932.x
Altman, 1965, Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats, J Comp Neurol, 124, 319, 10.1002/cne.901240303
Kuhn, 1996, Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation, J Neurosci, 16, 2027, 10.1523/JNEUROSCI.16-06-02027.1996
Altman, 1969, Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb, J Comp Neurol, 137, 433, 10.1002/cne.901370404
Doetsch, 1997, Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain, J Neurosci, 17, 5046, 10.1523/JNEUROSCI.17-13-05046.1997
Lim, 2016, The adult ventricular–subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis, Cold Spring Harb Perspect Biol, 8, 10.1101/cshperspect.a018820
Morshead, 1994, Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells, Neuron, 13, 1071, 10.1016/0896-6273(94)90046-9
Young, 2007, Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb, J Neurosci, 27, 8286, 10.1523/JNEUROSCI.0476-07.2007
Lugert, 2010, Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging, Cell Stem Cell, 6, 445, 10.1016/j.stem.2010.03.017
Furutachi, 2015, Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells, Nat Neurosci, 18, 657, 10.1038/nn.3989
Fuentealba, 2015, Embryonic origin of postnatal neural stem cells, Cell, 161, 1644, 10.1016/j.cell.2015.05.041
Moreno-Jiménez, 2019, Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease, Nat Med, 25, 554, 10.1038/s41591-019-0375-9
Ghazale, 2018, Docosahexaenoic acid (DHA) enhances the therapeutic potential of neonatal neural stem cell transplantation post—traumatic brain injury, Behav Brain Res, 340, 1, 10.1016/j.bbr.2017.11.007
Eady, 2012, Docosahexaenoic acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats, PLoS One, 7, e46151, 10.1371/journal.pone.0046151
Zhang, 2015, Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke, Exp Neurol, 272, 170, 10.1016/j.expneurol.2015.03.005
Nagata, 2011, DL-and PO-phosphatidylcholines as a promising learning and memory enhancer, Lipids Health Dis, 10, 25, 10.1186/1476-511X-10-25
Yuki, 2014, DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease, Sci Rep, 4, 7130, 10.1038/srep07130
Wen, 2016, DHA-PC and DHA-PS improved Aβ1–40 induced cognitive deficiency uncoupled with an increase in brain DHA in rats, J Funct Foods, 22, 417, 10.1016/j.jff.2016.02.004
Fourrier, 2017, Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro, J Neuroinflamm, 14, 170, 10.1186/s12974-017-0939-x
Van, 2019, Targeting the brain with a neuroprotective omega-3 fatty acid to enhance neurogenesis in hypoxic condition in culture, Mol Neurobiol, 56, 986, 10.1007/s12035-018-1139-0
Zhou, 2018, Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet, J Nutr Biochem, 59, 64, 10.1016/j.jnutbio.2018.05.009
Meng, 2019, Comparative analyses of DHA‐phosphatidylcholine forage and liposomes on Alzheimer's disease in SAMP8 mice, Eur J Lipid Sci Technol, 121, 10.1002/ejlt.201800524
Patrick, 2019, Role of phosphatidylcholine-DHA in preventing apoe4-associated Alzheimer's disease, FASEB J, 33, 1554, 10.1096/fj.201801412R
Li, 2020, Role of Resolvins in the inflammatory resolution of neurological diseases, Frontiers in Pharmacology, 11, 612, 10.3389/fphar.2020.00612
Kim, 2020, Resolvin D3 promotes inflammatory resolution, neuroprotection, and functional recovery after spinal cord injury, Mol Neurobiol, 22, 1
Afshordel, 2015, Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging–impact of Bcl-2 and NPD-1 like metabolites, Prostaglandins Leukot Essent Fatty Acids, 92, 23, 10.1016/j.plefa.2014.05.008
Zhou, 2020, Neuroprotectin D1 protects against postoperative delirium-like behavior in aged mice, Front Aging Neurosci, 12, 1, 10.3389/fnagi.2020.582674
Gronert, 2008, Lipid autacoids in inflammation and injury responses: a matter of privilege, Mol Interv, 8, 28, 10.1124/mi.8.1.7
Serhan, 2014, Pro-resolving lipid mediators are leads for resolution physiology, Nature, 510, 92, 10.1038/nature13479
Czapski, 2016, The lipoxygenases: their regulation and implication in Alzheimer's disease, Neurochem Res, 41, 243, 10.1007/s11064-015-1776-x
Martini, 2014, Neuroprotective effects of lipoxin A4 in central nervous system pathologies, Biomed Res Int, 2014, 1, 10.1155/2014/316204
Livne-Bar, 2017, Astrocyte-derived lipoxins A 4 and B 4 promote neuroprotection from acute and chronic injury, J Clin Invest, 127, 4403, 10.1172/JCI77398