Paola Guglielmelli1, Alessandro Pancrazzi1, Gaetano Bergamaschi2, Vittorio Rosti2, Laura Villani2, Elisabetta Antonioli1, Alberto Bosi1, Giovanni Barosi2, Alessandro M. Vannucchi1
1Department of Haematology, University of Florence, Florence
2Laboratory of Clinical Epidemiology, Transplant Research Area, Unit of Internal Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy
Tóm tắt
SummaryThe clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co‐existed with JAK2V617F mutation. When compared with MPL wild‐type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.
