Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

Barry, M.A., Behnke, C.A. & Eastman, A. Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem. Pharmacol. 40, 2353–2362 (1990).

Hickman, J.A. et al. Apoptosis and cancer chemotherapy. Philos. Trans. R. Soc. Land. B. Biol. Sci. 345 (1313) 319–325 (1994).

Trauth, B.C. et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245, 301–305 (1989).

Debatin, K.-M., Goldman, C.K., Bamford, R., Waldmann, T.A. & Krammer, P.M. Monoclonal antibody-mediated apoptosis in adult T cell leukemia. Lancet 335, 497–500 (1990).

Debatin, K.-M., Goldman, C.K., Waldmann, T.A. & Krammer, P.H. APO-1 induced apoptosis of leukemia cells from patients with adult T cell leukemia. Blood 81, 2972–2977 (1993).

Krammer, P.H. et al. The role of APO-1-mediated apoptosis in the immune system. Immunol. Rev. 142, 175–191 (1994).

Dhein, J., Walczak, H., Bäumler, C., Debatin, K.M. & Krammer, P.H. Autocrine T cell suicide mediated by APO-1 (Fas/CD95). Nature 373, 438–441 (1995).

Oehm, A. et al. Purification and molecular cloning of the APO-1 surface antigen, a member of the TNF/NGF receptor superfamily. J. Biol. Chem. 267, 10709–10715 (1992).

Itoh, N. et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66, 233–243 (1991).

Klas, C., Debatin, K.M., Jonker, R.R. & Krammer, P.H. Activation interferes with the apoptotic pathway in mature human T cells. Int. Immunol. 5, 625–630 (1993).

Kischkel, F.C. et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins (CAP) form a death-inducing signalling complex (DISC) with the receptor. EMBO J. (in the press).

Suda, T., Takahashi, S., Golstein, P. & Nagata, S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75, 1169–1178 (1993).

Tanaka, M., Suda, T., Takahashi, T. & Nagata, S. Expression of the functional soluble form of human Fas ligand in activated lymphocytes. EMBO J. 14, 1129–1135 (1995).

Mariani, S.M., Matiba, B., Baumler, C. & Krammer, P.H. Regulation of cell surface APO-1/Fas (CD95) ligand expression by metalloproteases. Eur. J. Immunol. 25, 2303–2307 (1995).

Muller, C. et al. Cellular pharmacokinetics of doxorubicin in patients with chronic lymphocytic leukemia: Comparison of bolus administration and continuous infusion. Cancer Chemother. Pharmacol. 32, 379–384 (1993).

Cusack, B.J., Young, S.P., Driskell, J. & Olson, R.D. Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit. Cancer. Chemother. Pharmacol. 32, 53–58 (1993).

Skladanowski, A. & Konopa, J. Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumor cells. Biochem. Pharmacol. 46, 375–382 (1993).

Thakkar, N.S. & Potten, C.S. Abrogation of adriamycin toxicity in vivo by cy-cloheximide. Biochem. Pharmacol. 43, 1683–1691 (1992).

Debatin, K.-M. & Krammer, P.H. Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent antiapoptotic program. Leukemia 9 (5), 815–820 (1995).

Bose, R. et al. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signal. Cell 82, 405–414 (1995).

Cifone, M.G. et al. Apoptotic signaling through CD95 (Fas/APO-1) activates an acidic sphingomyelinase. Exp. Med. 177, 1547–1552 (1994)

Nicholson, D.W. et al. Identification and inhibition of ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37–43 (1995).

Nicoletti, I., Migliorati, G., Pagliacci, M.C., Grignani, F. & Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immun. Methods 139, 271–279 (1991).

Carbonari, M. et al. Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus-infection and cancer chemotherapy by a novel flow immunocytometric method. Blood 83, 1268–1277 (1994).

Herr, I. et al. Monitoring of CD95 (APO-1/FAS) ligand expression in human T cells by quantitative RT-PCR. Cell Death Diff. (in the press).