The trajectory of IGF‐1 across age and duration of type 1 diabetes
Tóm tắt
Individuals with type 1 diabetes may have low IGF‐1, related to insulinopenia and insulin resistance. There are few longitudinal studies of IGF‐1 levels to establish its pattern in type 1 diabetes with duration and age, and to examine whether IGF‐1 tracks within individuals over time. We examine age and duration trends, and the relationship of IGF‐1 to gender, glycaemic control, insulin level and other factors.
Participants in the Wisconsin Diabetes Registry Study, an incident cohort study of type 1 diabetes diagnosed May 1987–April 1992, were followed for up to 18 years with IGF‐1 samples up to age 45 for women and age 37 for men.
IGF‐1 is lower with type 1 diabetes than in normative samples. Although, the pattern across age resembles that in normative samples with a peak in adolescence and slow decline after age 20, the adolescent peak is delayed for women with type 1 diabetes. There was low to moderate tracking of IGF‐1 within an individual. Higher insulin dose was associated with higher IGF‐1 as was puberty, and female gender. Adjusted for these factors, IGF‐1 declined rapidly across early diabetes duration. Lower HbA1c was most strongly related to higher IGF‐1 at Tanner stages 1 and 2.
IGF‐1 is low in type 1 diabetes, with a delayed adolescent peak in women and is especially influenced by glycaemic control in early and pre‐adolescence. High variability within an individual is likely a challenge in investigating associations between IGF‐1 and long‐term outcomes, and may explain contradictory findings. Copyright © 2014 John Wiley & Sons, Ltd.
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