Cognitive dysfunction in patients with type 2 diabetes

Diabetes/Metabolism Research and Reviews - Tập 26 Số 7 - Trang 507-519 - 2010
Yael D. Reijmer1, Esther van den Berg2,1, Carla Ruis2,1, L. Jaap Kappelle1, Geert Jan Biessels1
1Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, The Netherlands
2Department of Experimental Psychology, Utrecht University, Utrecht, The Netherlands

Tóm tắt

AbstractPeople with diabetes mellitus are at increased risk of cognitive dysfunction and dementia. This review explores the nature and severity of cognitive changes in patients with type 2 diabetes. Possible risk factors such as hypo‐ and hyperglycemia, vascular risk factors, micro‐ and macrovascular complications, depression and genetic factors will be examined, as well as findings from brain imaging and autopsy studies. We will show that type 2 diabetes is associated with modest cognitive decrements in non‐demented patients that evolve only slowly over time, but also with an increased risk of more severe cognitive deficits and dementia. There is a dissociation between these two ‘types’ of cognitive dysfunction with regard to affected age groups and course of development. Therefore, we hypothesize that the mild and severe cognitive deficits observed in patients with type 2 diabetes reflect separate processes, possibly with different risk factors and aetiologies. Copyright © 2010 John Wiley & Sons, Ltd.

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10.2337/diacare.23.10.1486

10.2337/diacare.13.1.16

10.1017/S1355617707070312

10.1093/ageing/afl180

10.1037/0894-4105.16.2.208

10.1016/j.bbadis.2008.09.004

10.1001/jama.282.1.40

10.2337/dc08-2143

10.1159/000160959

10.1126/science.1736359

10.1159/000021991

10.2337/diacare.20.9.1388

10.1111/j.1464-5491.1995.tb00569.x

10.1111/j.1532-5415.1998.tb04536.x

10.1046/j.1464-5491.2001.00577.x

10.2337/diacare.24.9.1567

10.1001/archinte.160.2.174

10.1046/j.1532-5415.2003.51504.x

10.1076/anec.10.2.99.14458

10.1212/WNL.56.1.42

10.2337/diacare.24.2.366

10.1001/archinte.164.12.1327

10.1212/01.WNL.0000134666.64593.BA

10.1007/s00125-009-1571-9

10.1016/S0895-4356(03)00077-5

10.1080/13803390802537636

10.1093/brain/awh451

10.1001/archneur.60.10.1394

10.3233/JAD-2009-0981

10.1093/aje/154.7.635

10.1001/archneur.64.4.570

Yaffe K, 2006, Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women, J Nutr Health Aging, 10, 292

10.1212/01.WNL.0000144281.38555.E3

10.1016/S1474-4422(05)70284-2

10.1016/j.ejphar.2008.02.049

10.1212/WNL.45.6.1161

10.1212/WNL.53.9.1937

10.2337/diabetes.51.4.1256

10.1212/01.WNL.0000140291.86406.D1

10.1212/01.wnl.0000172914.08967.dc

10.1001/archneur.61.5.661

10.1017/S104161020200844X

10.1007/s00401-010-0654-5

10.2337/diacare.21.3.398

10.1016/S0197-4580(03)00004-6

10.2337/dc06-0915

10.1212/01.wnl.0000184521.80820.e4

10.1111/j.1464-5491.2007.02170.x

10.2337/diab.37.12.1595

10.2337/dc06-1190

10.1007/BF00402181

10.1001/archneur.62.7.1067

10.1161/01.ATV.20.10.2255

10.1212/01.WNL.0000140292.04932.87

10.2337/diacare.24.6.1069

10.1016/j.neurobiolaging.2007.02.004

10.1007/s00125-006-0537-4

10.1192/bjp.180.2.157

10.1007/s00125-006-0478-y

10.1007/s00125-006-0159-x

10.1002/1520-7560(2000)9999:9999<::AID-DMRR141>3.0.CO;2-X

10.1016/j.bbadis.2008.12.003

10.1016/S1474-4422(08)70021-8

10.1111/j.1532-5415.2008.01686.x

10.1159/000183842

10.2105/AJPH.91.1.76

10.2337/diacare.21.4.518

10.1046/j.1532-5415.2001.49096.x

10.1016/j.numecd.2007.12.005

10.1001/archinte.162.4.427

Berry EM, 1997, Dietary fatty acids in the management of diabetes mellitus, Am J Clin Nutr, 66, 10.1093/ajcn/66.4.991S

10.1212/WNL.52.1.78

10.1016/j.jns.2004.09.007

10.2105/AJPH.2004.055574

10.2337/diacare.28.3.726

10.1016/j.ejphar.2008.01.052

10.1093/ageing/afh100

10.2337/diabetes.52.1.149

10.2337/diabetes.55.04.06.db05-1323

10.2337/dc06-0506

10.1007/s00125-007-0602-7

10.1016/j.diabres.2008.08.020

10.2337/dc08-1153

10.1016/1056-8727(94)00078-6

10.2337/diacare.17.8.891

10.1136/bmj.37977.495729.EE

10.2337/diacare.28.1.71

10.1007/s00125-009-1323-x

10.1007/s00125-007-0894-7

10.1046/j.1464-5491.2003.01072.x

10.1007/s00125-007-0599-y

10.1002/9780470516270.ch2

10.1111/j.1463-1326.2004.00421.x

10.1038/nrendo.2009.182

10.1001/jama.2009.460

10.1007/s00125-009-1437-1

2007, The Diabetes Control and Complications Trial Research Group Long‐term effect of diabetes and its treatment on cognitive function, N Engl J Med, 356, 1842, 10.1056/NEJMoa066397

10.1007/s00125-007-0792-z

10.1002/dmrr.1009

10.1016/j.brainres.2009.05.032

10.1016/S0140-6736(96)90608-X

10.1001/archneur.55.9.1217

10.1111/j.1464-5491.2007.02049.x

10.1007/s00125-003-1128-2

10.1007/s00125-007-0714-0

10.1016/S0168-8227(01)00300-X

10.2337/dc08-0562

10.1136/bjo.2008.141994

10.1053/j.ajkd.2007.12.044

10.1001/jama.287.19.2570

10.1212/01.WNL.0000165985.97397.88

10.1007/s00125-006-0333-1

10.1016/j.jns.2009.02.337

Slooter AJ, 1997, Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population‐based investigation, JAMA, 277, 818, 10.1001/jama.1997.03540340052032

10.1212/01.WNL.0000149643.91367.8A

10.1001/archneurol.2007.29

10.1007/s00125-009-1497-2

10.1016/j.neurobiolaging.2005.01.004

10.1016/S0304-3940(03)00488-9

10.1385/JMN:23:3:213

10.1016/S0166-2236(00)01656-8

10.1016/j.brainresrev.2007.09.001

10.1016/j.ejphar.2004.02.056

10.1016/S1474-4422(04)00681-7

10.1038/nn2055

10.1016/j.ejphar.2008.02.050

10.1161/hs0102.101629

10.2337/dc06-1637

10.2337/diabetes.53.3.687

10.1007/s00125-003-1235-0

10.1161/01.STR.27.8.1274

10.1007/s00125-007-0688-y

10.1159/000098054

10.2337/dc06-2052

10.1161/STROKEAHA.107.498535

10.1093/brain/awl387

10.1016/j.ejphar.2007.11.085

10.2337/dc06-0243

10.1016/j.jns.2010.08.048

10.1002/jmri.21224

10.1002/dmrr.632

10.1212/01.wnl.0000247053.45483.4e

10.1111/j.1365-2990.2008.00948.x

Johnson PC, 1982, Thickened cerebral cortical capillary basement membranes in diabetics, Arch Pathol Lab Med, 106, 214

10.1016/j.bbadis.2008.08.005

10.1016/j.jns.2004.09.019

10.1212/01.wnl.0000257094.10655.9a

10.1002/ana.21208

10.1212/WNL.49.5.1306

10.1093/gerona/60.4.471

10.1007/s00125-009-1533-2

10.1111/j.1532-5415.1993.tb06480.x

10.1093/geronj/48.4.M117

10.1016/1056-8727(95)00106-9

10.1159/000067947

10.2337/diacare.29.02.06.dc05-1626

10.1212/01.wnl.0000224760.22802.e8

10.1111/j.1464-5491.2004.01322.x

10.2337/diacare.22.8.1273

10.1056/NEJMoa066397

10.1016/S1474-4422(08)70143-1

10.2337/diacare.25.7.1250

10.1016/j.jamda.2008.03.014

10.1073/pnas.0306996101

10.1016/j.nutres.2008.03.016

10.1007/s00125-009-1484-7

10.1111/j.1749-6632.1997.tb48496.x