A novel murine cathelin‐like protein expressed in bone marrow

FEBS Letters - Tập 391 - Trang 5-8 - 1996
Anna E. Popsueva1, Marina V. Zinovjeva1, Jan W.M. Visser2, J.Mark J.M. Zijlmans3, Willem E. Fibbe3, Alexander V. Belyavsky1,2
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, 117984 Moscow B-334, Russian Federation
2New York Blood Center, 310 East 67th Str., New York, NY, USA
3Department of Hematology, University Medical Center, Rijnsburgerweg 10, Leiden, The Netherlands

Tóm tắt

A novel cDNA encoding a putative secreted protein was isolated from murine bone marrow. The encoded protein named MCLP (urine athelin‐ike rotein) was found to be highly homologous to the pig cathelin, and to four neutrophil antimicrobial polypeptides: CAP 18, indolicidin, Bac 5 and FALL‐39. Secondary structure prediction studies identified a highly cationic region in the C‐terminal part of prepro‐MCLP with a tendency to adopt an amphipathic α‐helical conformation, as observed in many antimicrobial peptides. However, no antibacterial activity was observed with the synthetic peptide corresponding to this region of MCLP.

Tài liệu tham khảo

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FEBS Letters

Tập 391

5-8

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