Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis

Journal of Cell Biology - Tập 175 Số 2 - Trang 209-215 - 2006
Yinghua Ma1,2,3, Jianxue Li1, Isaac M. Chiu4, Yawen Wang1,2,3, Jacob A. Sloane1,2,3, Jining Lü5, Béla Kosaras1, Richard L. Sidman1,2, Joseph J. Volpe2,6, Timothy Vartanian1,2,3
11Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115
22Program in Neuroscience
33Center for Neurodegeneration and Repair,
44Center for Blood Research, Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115
55Pulmonary Center, Boston University School of Medicine, Boston, MA 02118
66Department of Neurology, Children's Hospital, Boston, MA 02115

Tóm tắt

Toll receptors in Drosophila melanogaster function in morphogenesis and host defense. Mammalian orthologues of Toll, the Toll-like receptors (TLRs), have been studied extensively for their essential functions in controlling innate and adaptive immune responses. We report that TLR8 is dynamically expressed during mouse brain development and localizes to neurons and axons. Agonist stimulation of TLR8 in cultured cortical neurons causes inhibition of neurite outgrowth and induces apoptosis in a dissociable manner. Our evidence indicates that such TLR8-mediated neuronal responses do not involve the canonical TLR–NF-κB signaling pathway. These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity.

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Thông tin xuất bản

Journal of Cell Biology

Tập 175 Số 2

209-215

Thông tin tác giả