Towards predictive stochastic dynamical modeling of cancer genesis and progression
Tóm tắt
Based on an innovative endogenous network hypothesis on cancer genesis and progression we have been working towards a quantitative cancer theory along the systems biology perspective. Here we give a brief report on our progress and illustrate that combing ideas from evolutionary and molecular biology, mathematics, engineering, and physics, such quantitative approach is feasible.
Tài liệu tham khảo
citation_journal_title=Int J Colorectal Disease; citation_title=Spontaneous regression of colorectal cancer: A review of cases from 1900 to 2005; citation_author=A.S. Abedelrazeq; citation_volume=22; citation_publication_date=2007; citation_pages=727-736; citation_doi=10.1007/s00384-006-0245-z; citation_id=CR1
citation_journal_title=J Phys; citation_title=Potential in stochastic differential equations: novel construction; citation_author=P. Ao; citation_volume=37; citation_publication_date=2004; citation_pages=L25-L30; citation_id=CR2
citation_journal_title=J Genetics and Genomics; citation_title=Global view of bionetwork dynamics: Adaptive landscape; citation_author=P. Ao; citation_volume=36; citation_publication_date=2009; citation_pages=1-11; citation_doi=10.1016/S1673-8527(09)60001-1; citation_id=CR3
citation_journal_title=Complexity; citation_title=On the existence of potential landscape in the evolution of complex systems; citation_author=P. Ao, C. Kwon, H. Qian; citation_volume=12; citation_publication_date=2007; citation_pages=19-27; citation_doi=10.1002/cplx.20171; citation_id=CR4
citation_journal_title=Medical Hypotheses; citation_title=Cancer as Robust Intrinsic State of Endogenous Molecular-Cellular Network Shaped by Evolution; citation_author=P. Ao, D. Galas, L. Hood, X.-M. Zhu; citation_volume=70; citation_publication_date=2008; citation_pages=678-684; citation_doi=10.1016/j.mehy.2007.03.043; citation_id=CR5
Auffray, C., Chen, Z., Hood, L. 2009. Systems medicine: The future of medical genomics and healthcare. Genome Medicine 1, article No. 2.
citation_journal_title=Science; citation_title=Systems biology: Attractors and democratic dynamics; citation_author=Y. Bar-Yam, D. Harmon, B. Bivort; citation_volume=323; citation_publication_date=2009; citation_pages=1016-1017; citation_doi=10.1126/science.1163225; citation_id=CR7
citation_journal_title=BMC Syst Biol; citation_title=Optimal enumeration of state space of finitely buffered stochastic molecular networks and exact computation of steady state landscape probability; citation_author=Y.F. Cao, J. Liang; citation_volume=2; citation_publication_date=2008; citation_pages=article No. 30; citation_doi=10.1186/1752-0509-2-30; citation_id=CR8
citation_journal_title=J Pediatrics; citation_title=Spontaneous remission of congenital leukemia; citation_author=J.G. Dinulos, D.S. Hawkins, B.S. Clark, J.S. Francis; citation_volume=131; citation_publication_date=1997; citation_pages=300-303; citation_doi=10.1016/S0022-3476(97)70170-7; citation_id=CR9
citation_title=Cancer: The Evolutionary Legacy; citation_publication_date=2001; citation_id=CR10; citation_author=M. Greaves; citation_publisher=Oxford University Press
citation_journal_title=J Cellular Physiology; citation_title=Genetic and epigenetic heterogeneity in cancer: A genome-centric perspective; citation_author=H.H.Q. Heng, S.W. Bremer, J.B. Stevens, K.J. Ye, G. Liu, C.J. Ye; citation_volume=220; citation_publication_date=2009; citation_pages=538-547; citation_doi=10.1002/jcp.21799; citation_id=CR11
citation_journal_title=Physical Biology; citation_title=Positive feedback, stochasticity and genetic competence; citation_author=R. Karmakar, I. Bose; citation_volume=4; citation_publication_date=2007; citation_pages=29-37; citation_doi=10.1088/1478-3975/4/1/004; citation_id=CR12
citation_title=Fuzzy Engineering; citation_publication_date=1997; citation_id=CR13; citation_author=B. Kosko; citation_publisher=Prentice-Hall
citation_journal_title=Proc Natl Acad Sci (USA); citation_title=Structure of stochastic dynamics near fixed points; citation_author=C. Kwon, P. Ao, D.J. Thouless; citation_volume=102; citation_publication_date=2005; citation_pages=13029-13033; citation_doi=10.1073/pnas.0506347102; citation_id=CR14
citation_journal_title=IEEE T Fuzzy Systems; citation_title=Dynamical cognitive network — an extension of fuzzy cognitive map; citation_author=Y. Miao, Z.Q. Liu, C.K. Siew, C.Y. Miao; citation_volume=9; citation_publication_date=2001; citation_pages=760-770; citation_doi=10.1109/91.963762; citation_id=CR15
citation_journal_title=Biophys J; citation_title=Reaction coordinates for the flipping of genetic switches; citation_author=M.J. Morelli, S. Tanase-Nicola, R.J. Allen, P.R. Wolde; citation_volume=94; citation_publication_date=2008; citation_pages=3413-3423; citation_doi=10.1529/biophysj.107.116699; citation_id=CR16
citation_journal_title=Chem Phys; citation_title=Analyzing single molecule trajectories on complex energy landscapes using replica correlation functions; citation_author=J.N. Onuchic, J. Wang, P.G. Wolynes; citation_volume=247; citation_publication_date=1999; citation_pages=175-184; citation_doi=10.1016/S0301-0104(99)00203-7; citation_id=CR17
citation_journal_title=Phys Chem Chem Phys; citation_title=Stochastic bifurcation, slow fluctuations, and bistability as an origin of biochemical complexity; citation_author=H. Qian, P.Z. Shi, J.H. Xing; citation_volume=11; citation_publication_date=2009; citation_pages=4861-4870; citation_doi=10.1039/b900335p; citation_id=CR18
citation_journal_title=J Natl Cancer Inst; citation_title=Ras and Seppuku in neuroibalstorma; citation_author=C.P. Reynolds; citation_volume=94; citation_publication_date=2002; citation_pages=319-321; citation_id=CR19
citation_journal_title=PLoS Comput Biol; citation_title=Funneled landscape leads to robustness of cell networks: Yeast cell cycle; citation_author=J. Wang, B. Huang, X.F. Xia, Z.R. Sun; citation_volume=2; citation_publication_date=2006; citation_pages=1385-1394; citation_id=CR20
citation_title=The Biology of Cancer; citation_publication_date=2007; citation_id=CR21; citation_author=R.A. Weinberg; citation_publisher=Taylor and Francis
citation_journal_title=Cell Mot Cytosk; citation_title=Causal mapping as a tool to mechanistically interpret phenomena in cell motility: Application to cortical oscillations in spreading cells; citation_author=G.E. Weinreb, T.C. Elston, K. Jacobson; citation_volume=63; citation_publication_date=2006; citation_pages=523-532; citation_doi=10.1002/cm.20143; citation_id=CR22
citation_journal_title=J Phy; citation_title=Existence and construction of dynamical potential in nonequilibrium processes without detailed balance; citation_author=L. Yin, P. Ao; citation_volume=39; citation_publication_date=2006; citation_pages=8593-8601; citation_doi=10.1088/0305-4470/39/27/003; citation_id=CR23
citation_journal_title=Physica; citation_title=Stochastic model of yeast cellcycle network; citation_author=Y.P. Zhang, M.P. Qian, Q. Ouyang, M.H. Deng, F.T. Li, C. Tang; citation_volume=219; citation_publication_date=2006; citation_pages=35-39; citation_id=CR24
citation_journal_title=Funct Integr Genom; citation_title=Calculating robustness of epigenetic states in phage lambda life cycle; citation_author=X.M. Zhu, L. Yin, L. Hood, P. Ao; citation_volume=4; citation_publication_date=2004; citation_pages=188-195; citation_id=CR25
Zhu, X.M., Hood, L., Galas, D., Ao, P. 2010. Construction of a molecular-cellular endogenous network prostate cancer model. To be published.