CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies

Blood - Tập 130 - Trang 285-296 - 2017
Diogo Gomes-Silva1,2,3,4, Madhuwanti Srinivasan1,2,3, Sandhya Sharma1,2,3, Ciaran M. Lee5, Dimitrios L. Wagner1,2,3, Timothy H. Davis5, Rayne H. Rouce1,2,3, Gang Bao5, Malcolm K. Brenner1,2,3, Maksim Mamonkin1,2,3,6
1Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX
2Texas Children’s Hospital, Houston, TX
3Houston Methodist Hospital, Houston, TX
4Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal
5Department of Bioengineering, Rice University, Houston, TX
6Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX

Tóm tắt

Key PointsGenomic disruption of CD7 prior to CAR transduction allows generation of CD7 CAR T cells without extensive self-antigen-driven fratricide. CD7 CAR T cells have robust activity against T-cell malignancies in vitro and in vivo.

Tài liệu tham khảo

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