Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

Blood - Tập 127 - Trang 1317-1324 - 2016
Caroline Marty1,2,3, Christian Pecquet4,5, Harini Nivarthi6, Mira El-Khoury1,2,3, Ilyas Chachoua4,5, Micheline Tulliez1,2,3, Jean-Luc Villeval1,2,3, Hana Raslova1,2,3, Robert Kralovics6, Stefan N. Constantinescu4,5, Isabelle Plo1,2,3, William Vainchenker1,2,3
1INSERM, Unité Mixte de Recherche (UMR) 1170, Villejuif, France;
2Université Paris-Saclay, UMR 1170, Villejuif, France;
3Gustave Roussy, UMR 1170, Villejuif, France;
4Signal Transduction and Molecular Hematology Unit, Ludwig Institute for Cancer Research, Brussels, Belgium
5de Duve Institute, Université catholique de Louvain, Brussels, Belgium
6CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

Tóm tắt

Key Points Calreticulin type I and type II mutants are drivers of the disease as they induce thrombocytosis in a retroviral mouse model. Thrombopoietin receptor MPL is required for calreticulin mutants to induce an essential thrombocythemia phenotype in transplanted mice.

Tài liệu tham khảo

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