Single-unit activity in the globus pallidus and neostriatum of the rat during performance of a trained head movement
Tóm tắt
Single-unit extracellular neuronal recordings were obtained from the globus pallidus (GP) and the neostriatum (NS) of rats while they performed a learned head movement in response to an auditory cue. In both GP and NS, units that altered their discharge rate in association with head movements and with the cues that triggered these head movements were prevalent. Frequently, the responses were directionally-specific (i.e., the magnitude or direction of change in firing rate of these neurons was substantially different for trials in which head movements were made to the left vs. the right). For some units, firing rates were altered only in response to the movement cue or only in association with head movements. However, the majority of neurons exhibited responses with both cue-related and movement-related components. Neuronal responses to the auditory cue usually were context-dependent, in that they did not occur if the same stimulus was presented when the animal was not performing the task. At least a small proportion of GP and NS neurons also appeared to exhibit context-dependent movement-related activity, in that responses occasionally were observed that were associated either with sensory-triggered head movements or with spontaneous head movements, but not with both. These data are consistent with previous suggestions that the activity of basal ganglia neurons during movement performance is highly dependent on the conditions associated with movement initiation. The data also indicate that the response characteristics of both GP and NS neurons in the rat are generally similar to those that have been described for basal ganglia neurons in primates and cats during sensory triggered movement tasks. However, the proportion of task-related neurons that exhibited responses with both movement-related and cue-related components was greater than has generally been reported in studies of cats and primates, suggesting that neurons with these response properties may be more predominant in the rat basal ganglia.
Tài liệu tham khảo
Aldridge JW, Anderson RJ, Murphy JT (1980) The role of the basal ganglia in controlling a movement initiated by a visually presented cue. Brain Res 192: 3–16
Alexander GE (1987) Selective neuronal discharge in monkey putamen reflects intended direction of planned limb movements. Exp Brain Res 67: 623–634
Amalric M, Conde H, Dormont JF, Farin D, Schmeid A (1984) Activity of caudate nucleus neurons in cat performing a reaction time task. Neurosci Lett 49: 253–258
Crutcher MD, DeLong MR (1984) Single cell studies of the primate putamen. II. Relations to direction of movement and pattern of muscular activity. Exp Brain Res 53: 244–258
Diana M, Garcia-Munoz M, Richards J, Freed CR (1989) Electro physiological analysis of dopamine cells from the substantia nigra pars compacta of circling rats. Exp Brain Res 74: 625–630
Dolbakyan E, Hernandez-Mesa N, Bures J (1977) Skilled forelimb movements and unit activity in motor cortex and caudate nucleus in rats. Neuroscience 2: 73–80
Hikosaka O, Samamoto M, Usui S (1989) Functional properties of monkey caudate neurons I. Activities related to saccadic eye movements. J Neurophysiol 61(4): 780–798
Kimura M (1986) The role of primate putamen neurons in the association of sensory stimuli with movement. Neurosci Res 3: 436–443
Kimura M (1990) Behaviorally contingent property of movement-related activity of the primate putamen. J Neurophysiol 63: 1277–1296
Kimura M, Rajkowski J, Evarts E (1984) Tonically discharging putamen neurons exhibit set-dependent responses. Proc Natl Acad Sci USA 81: 4998–5001
Lidsky TI, Buchwald NA, Hull CD, Levine MS (1975) Pallidal and entopeduncular single unit activity in cats during drinking. Electroenceph Clin Neurophysiol 39: 79–84
Lidsky TI, Manetto C (1987) Context-dependent activity in the striatum of behaving cats. In: Schneider JS, Lidsky TI (eds) Basal ganglia and behavior: sensory aspects of motor functioning. Hans Huber, Toronto, pp 123–133
Liles SL (1985) Activity of neurons in putamen during active and passive movements of wrist. J Neurophysiol 53(1): 217–236
McGeorge AJ, Faull RLM (1989) The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 29: 503–537
Miller JD, Sanghera MK, German DC (1981) Mesencephalic dopaminergic unit activity in the behaviorally conditioned rat. Life Sci 29: 1255–1263
Mitchell SJ, Richardson RT, Baker FH, DeLong MR (1987) The primate globus pallidus: neuronal activity related to direction of movement. Exp Brain Res 68: 491–505
Neafsey EJ, Hull CD, Buchwald NA (1978) Preparation for movement in the cat. II. Unit activity in the basal ganglia and thalamus. Electroenceph Clin Neurophysiol 44: 714–723
Rolls ET, Thorpe SJ, Maddison SP (1983) Responses of striatal neurons in the behaving monkey. I. Head of the caudate nucleus. Behav Brain Res 7: 179–210
Schultz W, Romo R (1988) Neuronal activity in the monkey striatum during initiation of movements. Exp Brain Res 71: 431–436
Smith JC, Williams DP, Jue SS (1976) Rapid oral mixing of glucose and saccharin by rats. Science 191: 304–305
West MO, Michael AJ, Knowles SE, Chapin JK, Woodward DJ (1987) Striatal unit activity and the linkage between sensory and motor events. In: Schneider JS, Lidsky TI (eds) Basal ganglia and behavior: sensory aspects of motor functioning. Hans Huber, Toronto, pp 27–35
West MO, Woodward DJ (1984) A technique for microiontophoretic study of single neurons in the freely moving rat. J Neurosci Meth 11: 179–186