Genotype to phenotype: a technological challenge

Annals of Applied Biology - Tập 142 Số 1 - Trang 33-39 - 2003
Ian Wilson1, Gary Barker1, Keith J. Edwards1
1School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK

Tóm tắt

SummaryOur ability to ascribe protein function from primary DNA sequence or to predict the wide‐ranging effects of up or down regulating a single gene is still almost non‐existent. While the acquisition of raw genomic data proceeds apace, our capacity for converting this information into useful knowledge is limited. Within the next few years this “gap” will no doubt become an issue with both company and government fund providers as the drive to maximise profit and justify public expenditure becomes harder to resist. What follows is a whistle stop tour of some of the technologies that may help researchers to bridge this genotype‐phenotype gap!

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Tài liệu tham khảo

10.1016/S0014-5793(02)03218-0

10.1105/tpc.12.5.647

10.1093/bioinformatics/btf881

10.1023/A:1022446021230

10.1016/0966-842X(96)10042-1

Bennetzen J L, 1987, Transposon tagging of maize regulatory and resistance genes using Mutator, Journal of Cellular Biochemistry, 16, 11B

10.1007/s001220051544

10.1101/gr.9.11.1135

10.1105/tpc.010410

10.1038/13833

10.1126/science.282.5389.699

10.1101/gr.10.8.1259

10.1038/418122a

10.1126/science.278.5338.680

Deutsch S, 2001, A cSNP map and database for human chromosome 21, Genome Research, 11, 300, 10.1101/gr.164901

10.1166/gl.2002.001

10.1038/364555a0

10.1073/pnas.94.13.6809

10.1038/nature00935

10.1104/pp.124.4.1570

10.1101/gr.9.9.868

10.1073/pnas.96.4.1486

10.1105/tpc.13.4.889

10.1073/pnas.92.6.1836

10.1104/pp.000729

LiB LynchJ Z KrespanW P HanafeyM K DolanM TingeyS V VogelJ M.1999.Mutator transposable elements preferentially insert into genes in the maize genome.41st Maize Genetics Conference Lake Geneva WI USA p.122.

10.1038/4447

10.1038/35015701

10.1038/82521

Meeley R B, 1995, Reverse genetics for maize, Maize Genetics Newsletter, 69, 67

10.1093/nar/25.14.2745

10.1038/ng813

10.1038/35001165

10.1007/BF02799430

10.1016/S1369-5266(02)00240-6

10.1016/S1369-5266(99)00049-7

10.1046/j.1365-313X.1998.00254.x

10.1023/A:1013338512484

10.1105/tpc.13.1.113

10.1073/pnas.93.20.10614

10.1073/pnas.97.21.11655

10.1046/j.1365-313X.2002.01359.x

10.1038/11743

10.1091/mbc.9.12.3273

10.1073/pnas.151244298

10.1038/90135

Velculescu V E, 1995, Serial analysis of gene expression, Science, 270, 448, 10.1126/science.270.5235.484

10.1105/tpc.12.8.1491

Wassom J J, 2000, Allelic variation in candidate genes associated with QTL for the maize anther culture response, MAYDICA, 45, 267

Wise R P, 1996, Mutator‐induced mutations of the rf1 nuclear fertility restorer of T‐cytoplasm maize alter the accumulation of T‐urf13 mitochondrial transcripts, Genetics, 143, 1383, 10.1093/genetics/143.3.1383

10.1038/nbt1297-1359

10.1126/science.1068037

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Annals of Applied Biology

Tập 142 Số 1

33-39

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