Body mass index and risk of renal cell cancer: A dose‐response meta‐analysis of published cohort studies
Tóm tắt
Obesity is accepted as one of the major risk factors for renal cell cancer (RCC). However, conflicting results persist for the pooled risks based on the results from case–control and cohort studies combined, and the exact shape of the dose–response relationship has not been clearly defined yet. To help elucidate the role of obesity, PubMed and Embase databases were searched for published cohort studies on associations between body mass index (BMI) and risk of RCC. Random‐effects models and dose‐response meta‐analyses were used to pool study results. Subgroup analyses were conducted by the available characteristics of studies and participants. Cohort studies (21) with 15,144 cases and 9,080,052 participants were identified. Compared to normal weight, the pooled relative risks and the corresponding 95% confidence intervals of RCC were 1.28(1.24–1.33) for preobesity and 1.77(1.68–1.87) for obesity, respectively. A nonlinear dose–response relationship was also found for RCC risk with BMI (
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Tài liệu tham khảo
Campbell SC, 2011, Campbell–walsh urology, 1414
Ildaphonse G, 2009, Obesity and kidney cancer risk in men: a meta‐analysis (1992–2008), Asian Pac J Cancer Prev, 10, 279
Mathew A, 2009, Obesity and kidney cancer risk in women: a meta‐analysis (1992–2008), Asian Pac J Cancer Prev, 10, 471
Obesity: preventing and managing the global epidemic, 2000, Report of a WHO consultation, World Health Organ Tech Rep Ser., 894, i
Zumoff B, 1988, Hormonal abnormalities in obesity, Acta Med Scand, 723, 153