The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

EMBO Journal - Tập 31 Số 10 - Trang 2261-2274 - 2012
Lucía Chávez‐Gutiérrez1,2, Leen Bammens1,2, Iryna Benilova1,2, Annelies Vandersteen3,4, Manasi Benurwar1,2, M. Borgers1,2, Sam Lismont1,2, Lujia Zhou1,2, Simon Van Cleynenbreugel1,2, Hermann Esselmann5, Jens Wiltfang5, Lutgarde Serneels1,2, Eric Karran1, Harrie J. M. Gijsen6, Joost Schymkowitz7, Frédéric Rousseau4,7, Kerensa Broersen3,8, Bart De Strooper1,2
1Center for Human Genetics (CME) and Leuven Institute for Neurodegenerative Diseases (LIND), University of Leuven (KUL); Leuven Belgium
2VIB Center for the Biology of Disease, Leuven, Belgium
3Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente; AE Enschede The Netherlands
4Switch Laboratory, Department of Cellular and Molecular Medicine, KULeuven; Leuven Belgium
5Department of Psychiatry and Psychotherapy, LVR-Clinics Essen, University of Duisburg-Essen; Essen Germany
6Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium
7VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB); Leuven Belgium
8Vrije Universiteit Brussel, Brussel, Belgium

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