Carbon Monoxide: a Putative Neural Messenger

American Association for the Advancement of Science (AAAS) - Tập 259 Số 5093 - Trang 381-384 - 1993
Ajay Verma1, David Hirsch2, Charles E. Glatt2, Gabriele V. Ronnett3, Solomon H. Snyder2
1Department of Neurology, Walter Reed Army Medical Center, Washington, DC 20307.
2Departments of Neuroscience, Pharmacology and Molecular Sciences, and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
3Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Tóm tắt

Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of messenger RNA for the constitutive form of heme oxygenase throughout the brain has been demonstrated. This localization is essentially the same as that for soluble guanylyl cyclase messenger RNA. In primary cultures of olfactory neurons, zinc protoporphyrin-9, a potent selective inhibitor of heme oxygenase, depletes endogenous guanosine 3′,5′-monophosphate (cGMP). Thus, carbon monoxide, like nitric oxide, may be a physiologic regulator of cGMP. These findings, together with the neuronal localizations of heme oxygenase, suggest that carbon monoxide may function as a neurotransmitter.

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American Association for the Advancement of Science (AAAS)

Tập 259 Số 5093

381-384

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