Multi-parametric MR assessment of T1 black holes in multiple sclerosis

Deutsche Zeitschrift für Nervenheilkunde - Tập 254 - Trang 1653-1659 - 2007
I. M. Vavasour1,2, D. K. B. Li1, C. Laule1, A. L. Traboulsee3, G. R. W. Moore4, A. L. MacKay1
1Dept. of Radiology, University of British Columbia, UBC Hospital, Vancouver, Canada
2MRI Suite, UBC Hospital, Vancouver, Canada
3Dept. of Medicine (Neurology), University of British Columbia, UBC Hospital, Vancouver, Canada
4Dept. of Pathology and Laboratory Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Vancouver, Canada

Tóm tắt

Chronic T1 hypointense lesions in multiple sclerosis (MS) are areas of severe tissue destruction. The purpose of this study was to compare total water content (WC),myelin water content (MWC), magnetization transfer ratio (MTR), T1 relaxation time (T1), mean T2 relaxation time (GMT2) between stable MS lesions that are hypointense and isointense on T1-weighted images. Six MS patients were scanned five times over one year. WC, MWC, MTR, T1 and GMT2 were calculated for 15 isointense and 15 hypointense chronically stable T1 lesions, as well as contralateral normal appearing white matter (NAWM). All MR measurements from both iso- and hypointense stable lesion types were significantly different from NAWM. WC, T1 and GMT2 were significantly higher and MTR significantly lower in hypointense T1 lesions compared to isointense lesions. MWC was not significantly different between iso- and hypointense lesions. This work suggests that myelin loss occurs equally in both the chronic isointense and hypointense lesions but hypointense lesions are distinguished by increased extracellular water.

Tài liệu tham khảo

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