Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

Blood - Tập 123 - Trang 2220-2228 - 2014
Pontus Lundberg1, Axel Karow1, Ronny Nienhold1, Renate Looser1, Hui Hao-Shen1, Ina Nissen2, Sabine Girsberger3, Thomas Lehmann3, Jakob Passweg3, Martin Stern1,3, Christian Beisel2, Robert Kralovics4,5, Radek C. Skoda1,3
1Experimental Hematology, Department of Biomedicine, University Hospital of Basel, Basel, Switzerland
2Department of Biosystems Science and Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland
3Division of Hematology, University Hospital Basel, Basel, Switzerland
4CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences, Vienna, Austria
5Division of Hematology and Blood Coagulation, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria

Tóm tắt

Key Points The total number of somatic mutations was inversely correlated with survival and risk of leukemic transformation in MPN. The great majority of somatic mutations were already present at MPN diagnosis, and very few new mutations were detected during follow-up.

Tài liệu tham khảo

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