Jean‐Richard Goulet1, Arlyn W. Kinkel1, Teresa Smith1
1Parke, Davis & Company Research Laboratories, Ann Arbor and Detroit, Mich.
Tóm tắt
Twenty subjects, in a double‐blind, controlled, rising dose study, were given ethosuximide either once daily or 3 times daily. Steady‐state plasma levels and urinary throughput were proportional to dose and were equivalent whether the daily dose was given as a single or a divided dose. This finding adds validity to consideration of the single daily dose regimen as a therapeutic possibility. The metabolic principles should be considered both in patient management and in the treatment of overdosage.
