Mitochondria and Apoptosis

American Association for the Advancement of Science (AAAS) - Tập 281 Số 5381 - Trang 1309-1312 - 1998
Douglas R. Green1, John C. Reed1
1D. R. Green is at the La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA. J. C. Reed is at the Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Tóm tắt

REVIEW A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.

Từ khóa


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Because of space limitations it was not possible to include a comprehensive list of references for all the work discussed. We apologize to those many authors whose important contributions could not be described or properly cited.

We thank G. Kroemer and M. Degli Esposti for invaluable discussions and C. Thompson and H. Beere for critically reading the manuscript.