Comparison of the Repeated Dose Toxicity of Isomers of Dinitrotoluene

International Journal of Toxicology - Tập 31 Số 2 - Trang 143-157 - 2012
Emily May Lent1, Lee C. B. Crouse1, Michael J. Quinn1, Shannon M. Wallace1
1US Army Public Health Command, Toxicology Portfolio, Aberdeen Proving Ground, MD, USA

Tóm tắt

Dinitrotoluene (DNT) is a nitroaromatic explosive used in propellant mixtures and in the production of plastics. Isomers of DNT were administered daily via oral gavage to male Sprague-Dawley rats for 14 days to determine the subacute toxicity of individual isomers of DNT. The 3,5-DNT isomer was the most toxic isomer, inducing weight loss and mortality within 3 days. Cyanosis and anemia were observed for all isomers. Exposure to 2,4-, 2,6-, and 3,5-DNT resulted in decreased testes mass and degenerative histopathological changes. Increased splenic mass was observed for 2,4-, 2,6-, and 2,5-DNT. Extramedullary hematopoiesis of the spleen was noted for all isomers, while lymphoid hyperplasia of the spleen was noted for all isomers except 2,5-DNT. Increased liver mass was observed for 2,3-DNT and 3,4-DNT. Hepatocellular lesions were observed for 2,6-DNT and 2,4-DNT. Neurotoxic effects were noted for 3,4-DNT, 2,4-DNT, and 3,5-DNT.

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International Journal of Toxicology

Tập 31 Số 2

143-157

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