Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

Baxter, 2005, Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders., Lancet, 365, 1054, 10.1016/S0140-6736(05)71142-9 James, 2005, A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera., Nature, 434, 1144, 10.1038/nature03546 Kralovics, 2005, A gain-of-function mutation of JAK2 in myeloproliferative disorders., N Engl J Med, 352, 1779, 10.1056/NEJMoa051113 Levine, 2005, Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis., Cancer Cell, 7, 387, 10.1016/j.ccr.2005.03.023 Pardanani, 2006, MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients., Blood, 108, 3472, 10.1182/blood-2006-04-018879 Pikman, 2006, MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia., PLoS Med, 3, e270, 10.1371/journal.pmed.0030270 Scott, 2007, JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis., N Engl J Med, 356, 459, 10.1056/NEJMoa065202 Teofili, 2007, Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation., Blood, 110, 354, 10.1182/blood-2007-01-069237 Heller, 2006, JAK2V617F mutation in platelets from essential thrombocythemia patients: correlation with clinical features and analysis of STAT5 phosphorylation status., Eur J Haematol, 77, 210, 10.1111/j.1600-0609.2006.00688.x Mesa, 2006, Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia., Leukemia, 20, 1800, 10.1038/sj.leu.2404338 Rudd, 2001, Lnk adaptor: novel negative regulator of B cell lymphopoiesis., Sci STKE, 2001, PE1, 10.1126/stke.2001.85.pe1 Bersenev, 2008, Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2., J Clin Invest, 118, 2832 Gery, 2007, Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders., Blood, 110, 3360, 10.1182/blood-2007-05-089326 Takaki, 2002, Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk., J Exp Med, 195, 151, 10.1084/jem.20011170 Velazquez, 2002, Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice., J Exp Med, 195, 1599, 10.1084/jem.20011883 Tong, 2004, Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis., J Exp Med, 200, 569, 10.1084/jem.20040762 Irish, 2004, Single cell profiling of potentiated phospho-protein networks in cancer cells., Cell, 118, 217, 10.1016/j.cell.2004.06.028 Kotecha, 2008, Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates., Cancer Cell, 14, 335, 10.1016/j.ccr.2008.08.014 Jamieson, 2006, The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation., Proc Natl Acad Sci USA, 103, 6224, 10.1073/pnas.0601462103 Tong, 2005, Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways., Blood, 105, 4604, 10.1182/blood-2004-10-4093 Takizawa, 2006, Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk., Blood, 107, 2968, 10.1182/blood-2005-05-2138