Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats

Brain Research - Tập 643 Số 1-2 - Trang 194-203 - 1994
Cheryl A. Frye1,2, Jennifer E. Duncan1,2
1Department of Biology, Boston University, Boston, MA 02215 USA
2Department of Psychology. Bates College, Lewiston, ME, 04240 USA

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Bardin, 1987, Pro-opiomelanocortin derived peptides in testis, ovary and tissues of reproduction, Recent Prog. Horm. Res., 43, 1

Belelli, 1990, Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex, Neurosci. B., 14, 315

Berge, 1988, Response latencies in the tail-flick test depend on tail skin temperature, Neurosci. Lett., 86, 284, 10.1016/0304-3940(88)90497-1

Bitran, 1993, Blockade of bioconversion of P to allopregnanolone prevents the anxiolytic effect and P degradation of cortical GABAA receptor function observed in P-treated ovx rats, Soc. Neurosci. Abstr.

Bitran, 1993, Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function, Pharm. Biochem. B., 45, 423, 10.1016/0091-3057(93)90260-Z

Bitran, 1991, Anxiolytic effects of 3α-hydroxy-5α-pregnan-20-one, endogenous metabolite of progesterone that are active at the GABA receptor, Brain Res., 561, 157, 10.1016/0006-8993(91)90761-J

Bowers, 1992, Biochemical and behavioral effects of steroids on GABAA receptor function in long- and short-sleep mice, Brain Res. B., 29, 5768

Britton, 1992, Pregnane steroid alphaxalone attenuates anxiogenic behavioral effects of corticotropin releasing factor and stress, Pharm. Bio. B, 41, 399, 10.1016/0091-3057(92)90117-X

Britton, 1991, Anxiolytic activity of steroid anesthetic alphaxalone, J. Pharm. Exp., 258, 124

Bush, 1962, Chemical and biological factors in the activity of adrenocortical steroids, Pharmacol. Rev., 14, 317

Carlson, 1983, A study of the interaction between progesterone and membrane lipids, Endocrinology, 117, 190, 10.1210/endo-113-1-190

Crawley, 1986, Anxiolytic activity of an endogenous adrenal steroid, Brain Res., 398, 382, 10.1016/0006-8993(86)91500-3

Erskine, 1992, Stress and ACTH increase circulating concentrations of 3α-androstanediol in female rats, Life Sci., 51, 2065, 10.1016/0024-3205(92)90157-K

Etgen, 1984, Progestin receptors and the activation of female reproductive behavior: a critical review, Hormone Beh., 18, 411, 10.1016/0018-506X(84)90027-8

Franklin, 1989, Techniques for assessing the effects of drugs on nociceptive responses, 145

Frye, 1993, Diet and estrous cycle influence pain sensitivity in rats, Pharm. Bio. B., 45, 255, 10.1016/0091-3057(93)90116-B

Frye, 1992, Hormonal milieu affects tailflick latency in female rats and may be attenuated by access to sucrose, Physiol. Behav., 52, 699, 10.1016/0031-9384(92)90400-V

Gee, 1988, Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action, J. Pharmacol. Exp. Ther., 246, 803

Gintzler, 1990, Pain thresholds are elevated during pseudopregnancy, Brain Res., 507, 312, 10.1016/0006-8993(90)90288-M

Gintzler, 1980, Endorphin mediated increase in pain threshold during pregnancy, Science, 210, 193, 10.1126/science.7414330

Gyermeck, 1968, Structure-activity relationships and some steroidal hypnotic agents, Steroids, 11, 117

Gyermeck, 1967, Some effects of progesterone and related steroids on the central nervous system, Int. J. Neuropharmacol., 6, 191, 10.1016/0028-3908(67)90005-6

Hammond, 1989, Inference of pain and its modulation from simple behaviors, 6

Harrison, 1984, Modulation of the GABA receptor complex by a steroid anesthetic, Brain Res., 323, 287, 10.1016/0006-8993(84)90299-3

Hogskilde, 1987, Anesthetic properties of pregnanolone emulsion, Anesthesia, 42, 1045, 10.1111/j.1365-2044.1987.tb05166.x

Holzbauer, 1985, In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, potent anaesthetic steroid, by the adrenal gland of the rat, J. Steroid B., 22, 97, 10.1016/0022-4731(85)90147-5

Ichikawa, 1974, Ovarian secretion of pregnane compounds during the estrous cycle and pregnancy in rats, Endocrinology, 94, 1615, 10.1210/endo-94-6-1615

Im, 1990, Studies on the mechanism of interactions between anesthetic steroids and γ-aminobutyric acid receptors, Mol. Pharmacol., 37, 429

Iswari, 1986, Binding of 5α-dihydroprogesterone and other progestins to female rat anterior pituitary nuclear extracts, Steroids, 47, 189, 10.1016/0039-128X(86)90088-7

Karavolas, 1976, Progesterone metabolism by neuroendocrine tissues, 305

Kavaliers, 1988, Inhibitory influences of the adrenal steroid, 3α,5α-tetrahydroxycorticosterone on aggression and defeat-induced analgesia in mice, Psychopharmacology, 95, 488, 10.1007/BF00172960

Kavaliers, 1987, Analgesic effects of the progesterone metabolite, 3α-hydroxy-5α-pregnan-20-one and possible modes of action in mice, Brain Res., 415, 393, 10.1016/0006-8993(87)90228-9

Klimek, 1985, Use of testosterone in the treatment of cluster headache, Eur. Neurol., 24, 53, 10.1159/000115761

Klimek, 1984, Hormonal status in cluster headache, Vol. 2, 215

Krey, 1975, Surgical disconnections of the medial basal hypothalamus and pituitary function in the rhesus monkey. II. Gh and cortisol secretion, Endocrinology, 96, 1088, 10.1210/endo-96-5-1088

Korneyev, 1993, Inhibition of 5α reductase suppresses progesterone induced anesthesia by blocking the accumulation of brain allopregnanolone, Soc. Neurosci. Abstr.

Lee, 1990, Progesterone enhances the surge of leuteinizing hormone by increasing the activation of leuteinizing hormone releasing hormone neurons, Endocrinology, 127, 2604, 10.1210/endo-127-5-2604

Le Mevel, 1978, Dynamic changes in plasma adrenocorticotropin after neurotropic stress in male and female rats, J. Endocrinol., 76, 359, 10.1677/joe.0.0760359

Majewska, 1992, Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance, Prog. Neurob., 38, 379, 10.1016/0301-0082(92)90025-A

Majewska, 1986, Steroid hormone metabolites are bartiturate-like modulators of the GABA receptor, Science, 232, 1004, 10.1126/science.2422758

Marshall, 1974, Further analysis of sensory inattention following hypnotic damage in rats, J. Comp. Physiol. Psych., 86, 375, 10.1037/h0035941

McEwen, 1978, Cellular biochemistry of hormone action in brain and pituitary, 415

Mendelson, 1987, Sleep induction by an adrenal steroid in the rat, Psychopharmacology, 93, 226, 10.1007/BF00179939

Meyerson, 1967, Relationship between the anesthetic and gestagenic action and estrous-inducing activity of different progestins, Endocrinology, 81, 369, 10.1210/endo-81-2-369

Mok, 1992, Evidence that 5α-pregnan-3α-ol-20-one is the metabolite responsible for anesthesia induced by 5α-pregnanedione in the mouse, Neurosci. Lett., 135, 145, 10.1016/0304-3940(92)90423-5

Mok, 1991, In vivo studies identify 5α-pregnan-3α-ol-20-one as an active anesthetic agent, J. Neurochem., 57, 12961301, 10.1111/j.1471-4159.1991.tb08293.x

Morrow, 1990, Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites, Mol. Pharm., 37, 263

Morrow, 1987, Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency, Eur. J. Pharm., 142, 483, 10.1016/0014-2999(87)90094-X

Mueller, 1980, Attenuated pituitary, β-endorphin release in estrogen-treated rats, 165, 75

Norberg, 1987, The anaesthetic potency of 3α-hydroxy-5β-pregnan-20-one determined with an intravenous EEG-threshold method in male rats, Pharm. Tox., 61, 42, 10.1111/j.1600-0773.1987.tb01770.x

Olsen, 1990, Molecular biology of GABAA receptors, FASEB J., 4, 1469, 10.1096/fasebj.4.5.2155149

Paxinos, 1986

Polleri, 1992, Pain and sex steroids, Vol. 20, 253

Purdy, 1991, Stress-induced levels of γ-aminobutyric acid type A receptor-active steroids in the rat brain, 88, 4553

Purdy, 1990, Synthesis, metabolism and pharmacological activity of 3α-hydroxy steroids which potentiate GABA-receptor chloride ion uptake in rat cerebral cortical synaptoneurosomes, J. Med. Chem., 33, 1572, 10.1021/jm00168a008

Richards, 1975, Implications for theories of anaesthesia of antagonism between anaesthetic and non-anaesthetic steroid, Nature, 256, 179, 10.1038/256179a0

Rodriquez-Sierra, 1984, Effect of ovarian hormones on conflict behavior, Psychoneuropharmacology, 9, 293

Schultze, 1987, Are Leydig cells of neural orgin: substance P-like immunoreactivity in human testicular tissue, Acta Endocrinol., 115, 373, 10.1530/acta.0.1150373

Selye, 1941, Anaesthetic effects of steroid hormones, 46, 116

Shoupe, 1985, The effects of estrogen and progestin on endogenous opioid activity in oophorectomized women, J. Clin. End., 60, 178, 10.1210/jcem-60-1-178

Sicuti, 1988, Antoandrogenic medication in cluster headache, Int. J. Clin. Pharm. Res., 8, 21

Turner, 1989, Steroid aenesthetics and naturally occuring analogs modulate the GABA receptor complex at a sie distinct from barbiturates, J. Pharmacol. Exp. Ther., 248, 960

Viau, 1991, Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat, Endocrinology, 129, 2503, 10.1210/endo-129-5-2503

Wardlaw, 1982, Effects of sex steroids on brain β-endorphin, Brain Res., 245, 327, 10.1016/0006-8993(82)90815-0

Wardley-Smith, 1985, In vivo interactions between the benzodiazepine antagonist Ro 15–1788 and the steroid anaesthetic althesin in rats, Br. J. Anaest., 57, 629, 10.1093/bja/57.6.629

Waud, 1970, On dose-response curves in anesthetics, J. Anest., 33, 1, 10.1097/00000542-197007000-00001

Wieland, 1991, Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one, Brain Res., 565, 263, 10.1016/0006-8993(91)91658-N

Wolfson, 1971, Brain anesthetic concentration- a new concept, Anesthesiology, 36, 176, 10.1097/00000542-197202000-00022

Wormald, 1989, Substance P receptors in human pituitary: a potential inhibitor of luteinizing hormone secretion, J. Clin. End., 69, 612, 10.1210/jcem-69-3-612