B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

American Association for the Advancement of Science (AAAS) - Tập 6 Số 248 - 2014
Joel N. H. Stern1, Gur Yaari2,3, Jason A. Vander Heiden4, George M. Church5, William F. Donahue6, Rogier Q. Hintzen7, Anita Hüttner3, Jon D. Laman8, Rashed M. Nagra9, Alyssa Nylander1, David Pitt1, Sriram Ramanan1, Bilal A. Siddiqui1, François Vigneault6,5, Steven H. Kleinstein3,4, David A. Hafler10,1, Kevin C. O’Connor1
1Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA
2Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan 52900, Israel
3Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA
4Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA
5Department of Genetics, Harvard Medical School, Boston, MA 02115 USA
6AbVitro Incorporated, Boston, MA 02210, USA.
7Department of Neurology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
8Department of Immunology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands.
9Neurology Research, West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA
10Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.

Tóm tắt

In multiple sclerosis patients, B cells mature in the draining cervical lymph nodes before trafficking across the blood-brain barrier.

Từ khóa


Tài liệu tham khảo

10.1172/JCI58649

10.1016/S0065-2776(08)00404-5

10.1111/j.1750-3639.2004.tb00049.x

10.1093/brain/awr182

10.1056/NEJMoa1110740

10.4049/jimmunol.0801888

10.1056/NEJMoa0706383

10.1126/science.1222794

10.1111/j.1600-065X.2008.00646.x

10.1093/brain/awq350

10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q

10.1093/brain/awm038

10.4049/jimmunol.171.5.2725

10.1016/j.jneuroim.2011.01.010

10.1172/JCI63842

10.1002/ana.24088

10.1007/s00109-008-0421-4

10.4049/jimmunol.169.10.5415

Prineas J. W., Wright R. G., Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis. Lab. Invest. 38, 409–421 (1978).

10.1172/JCI3568

Baranzini S. E., Jeong M. C., Butunoi C., Murray R. S., Bernard C. C., Oksenberg J. R., B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J. Immunol. 163, 5133–5144 (1999).

10.1093/neuonc/not110

10.4049/jimmunol.0803424

10.1093/nar/gks457

10.1016/j.jneuroim.2008.04.031

10.1002/ana.410430214

10.1084/jem.173.2.395

10.1093/brain/awm214

10.1182/blood-2010-07-294249

10.1038/nm1714

10.1002/ana.21641

10.1016/j.jneuroim.2007.03.002

10.1002/eji.200737784

10.1038/nm1344

10.1212/WNL.0b013e3182a43b48

10.4049/jimmunol.178.1.547

10.4049/jimmunol.174.5.2860

10.1002/ana.10685

Burgoon M. P., Owens G. P., Smith-Jensen T., Walker D., Gilden D. H., Cloning the antibody response in humans with inflammatory central nervous system disease: Analysis of the expressed IgG repertoire in subacute sclerosing panencephalitis brain reveals disease-relevant antibodies that recognize specific measles virus antigens. J. Immunol. 163, 3496–3502 (1999).

10.1016/j.cell.2013.10.034

10.1002/eji.201142108

10.1177/1352458511428465

10.1177/1352458512463483

10.1001/archneurol.2011.971

10.1093/bioinformatics/btu138

10.1007/978-1-61779-842-9_32

10.4049/jimmunol.156.7.2642

10.2307/1934352

Felsenstein J., PHYLIP—Phylogeny Inference Package (Version 3.2). Cladistics 5, 164–166 (1989).

Csárdi G., Nepusz T., The igraph software package for complex network research. InterJ. Complex Syst. 1695 (2006).

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American Association for the Advancement of Science (AAAS)

Tập 6 Số 248

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