Cyclooxygenase‐dependent signalling: molecular events and consequences

FEBS Letters - Tập 445 - Trang 1-5 - 1999
Henri H Versteeg1,2, Paul M.P van Bergen en Henegouwen2, Sander J.H van Deventer1, Maikel P Peppelenbosch1
1Laboratory for Experimental Internal Medicine, Academic Medical Centre, G2-130, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
2Department of Molecular Cell Biology, Institute for Biomembranes and Lipid Biology, Utrecht University, Padualaan 8, Utrecht, The Netherlands

Tóm tắt

Non‐steroidal anti‐inflammatory drugs (NSAIDs) currently attract large interest. Next to pain relief, NSAIDs have important anti‐thrombotic and anti‐oncogenic effects. NSAIDs exert their action by inhibition of cyclooxygenase, the enzyme responsible for the production of prostanoids. Prostanoid signal transduction is still poorly understood, but it has become clear that these inflammatory lipids influence cellular physiology at three different levels: (1) activation of a 7× transmembrane receptor coupled to heterotrimeric G proteins, (2) the inhibition of inflammation by activating corticosteroid‐like receptors, (3) participation in receptor protein tyrosine kinase signal transduction. In this review prostanoid signalling at these three different levels will be reviewed and the relevance in (patho)physiological processes will be evaluated.

Tài liệu tham khảo

10.1126/science.6753151 10.3181/00379727-208-43845 10.1007/BF00872387 10.1006/excr.1995.1146 10.1016/0163-7258(91)90054-P 10.1074/jbc.270.18.10902 10.1016/0003-9861(92)90411-O 10.1016/S0021-9258(18)42398-8 Smith W.L., 1992, Am. J. Physiol., 263, F181 10.1016/0014-5793(93)80263-T 10.1016/0005-2760(91)90032-D 10.1006/bbrc.1993.1483 10.1074/jbc.270.14.8044 10.1016/S0021-9258(17)31786-6 10.1096/fasebj.5.9.1907252 10.1016/S0021-9258(18)68959-8 10.1016/0092-8674(95)90126-4 10.1016/S0021-9258(18)35698-9 10.1016/S0021-9258(19)38515-1 10.1002/ddr.430250402 10.1016/0092-8674(95)90125-6 10.1016/0092-8674(95)90127-2 10.1053/gast.1996.v110.pm8613017 10.1016/S0092-8674(00)81988-1 10.1093/carcin/19.1.49 Coleman R.A. Kennedy I. Humphrey P.P.A. Bunce K. and Lumley P. (1990) Comp. Med. Chem. Membranes and Receptors Vol. 3 pp. 643–714 Pergamon Press Oxford. 10.1038/36342 10.1042/bj2850529 10.1016/0090-6980(92)90142-G 10.1016/0929-7855(96)00512-3 10.1111/j.1476-5381.1989.tb11817.x Mayeux P.R., 1989, J. Pharmacol. Exp. Ther., 250, 923 10.1016/S0021-9258(20)80710-8 10.1016/S0021-9258(19)74379-8 10.1182/blood.V78.9.2328.2328 Ushikubi F., 1994, Mol. Pharmacol., 46, 808 10.1073/pnas.91.2.504 10.1016/S0021-9258(19)74486-X 10.1016/0929-7855(96)00512-3 10.1016/0006-2952(93)90495-I 10.1016/0167-4889(94)00198-N 10.1016/0896-6273(92)90118-W 10.1038/365166a0 10.1016/S0021-9258(19)74279-3 10.1128/MCB.15.1.351 10.1038/358771a0 10.1038/34178 10.1038/34184 10.1038/23948 10.1016/S0092-8674(00)81575-5 10.1038/2042 10.1038/2036 10.1038/2030 10.1016/0092-8674(93)80057-L 10.1074/jbc.271.1.505 10.1002/hep.510230545 10.1016/S0021-9258(19)39645-0 Muthalif M.M., 1998, J. Pharmacol. Exp. Ther., 284, 388
Thông tin
Thông tin xuất bản

FEBS Letters

Tập 445

1-5

Thông tin tác giả