The human cerebellum and associative learning: dissociation between the acquisition, retention and extinction of conditioned eyeblinks

V. Bracha, J.R. Bloedel, The multiple pathway model of circuits subserving the classical conditioning of withdrawal reflexes, in: J.R. Bloedel, T.J. Ebner, S.P. Wise (Eds.), Acquisition of Motor Behavior in Vertebrates, MIT Press, Cambridge, 1996, pp. 175–204. Bracha, 1998, Retention of conditioned responses in patients with cerebellar lesions: the kinesthetic threat eyeblink response, Soc. Neurosci. Abstr., 24, 1409 Bracha, 1997, Patients with cerebellar lesions cannot acquire but are able to retain conditioned eyeblink reflexes, Brain, 120, 1401, 10.1093/brain/120.8.1401 Daum, 1993, Classical conditioning after cerebellar lesions in humans, Behav. Neurosci., 107, 748, 10.1037/0735-7044.107.5.748 Hardiman, 1996, Reversible inactivations of the cerebellum with muscimol prevent the acquisition and extinction of conditioned nictitating membrane responses in the rabbit, Exp. Brain Res., 110, 235, 10.1007/BF00228555 J.A. Harvey, J.P. Welsh, Learning and performance: a critical review of the role of the cerebellum in instrumental and classical conditioning, in: J.R. Bloedel, T.J. Ebner, S.P. Wise (Eds.), The Acquisition of Motor Behavior in Vertebrates, The MIT Press, Cambridge, MA, 1996, pp. 115–142. Llinás, 1993, On the cerebellum and motor learning, Curr. Opin. Neurobiol., 3, 958, 10.1016/0959-4388(93)90168-X Logan, 1995, Functional anatomy of human eyeblink conditioning determined with regional glucose metabolism and positron emission tomography, Proc. Natl. Acad. Sci., 92, 7500, 10.1073/pnas.92.16.7500 Mauk, 1997, A model of pavlovian eyelid conditioning based on the synaptic organization of the cerebellum, Learn. Mem., 3, 130, 10.1101/lm.4.1.130 Molchan, 1994, A functional anatomical study of associative learning in humans, Proc. Natl. Acad. Sci., 91, 8122, 10.1073/pnas.91.17.8122 Perrett, 1995, Extinction of conditioned eyelid responses requires the anterior lobe of cerebellar cortex, J. Neurosci., 15, 2074, 10.1523/JNEUROSCI.15-03-02074.1995 Ramnani, 1996, Reversible inactivations of the cerebellum prevent the extinction of conditioned nictitating membrane responses in rabbits, J. Physiol. (London), 495, 159, 10.1113/jphysiol.1996.sp021581 Raymond, 1996, The cerebellum: a neuronal learning machine?, Science, 272, 1126, 10.1126/science.272.5265.1126 Schreurs, 1997, Lateralization and behavioral correlation of changes in regional cerebral blood flow with classical conditioning of the human eyeblink response, J. Neurophysiol., 77, 2153, 10.1152/jn.1997.77.4.2153 Solomon, 1989, Disrupted eyelid conditioning in a patient with damage to cerebellar afferents, Behav. Neurosci., 103, 898, 10.1037/0735-7044.103.4.898 Thompson, 1986, The neurobiology of learning and memory, Science, 233, 941, 10.1126/science.3738519 Thompson, 1994, Organization of memory traces in the mammalian brain, Annu. Rev. Neurosci., 17, 519, 10.1146/annurev.ne.17.030194.002511 Yeo, 1985, Classical conditioning of the nictitating membrane response of the rabbit: I. Lesions of the cerebellar nuclei, Exp. Brain Res., 60, 87, 10.1007/BF00237022 Yeo, 1985, Classical conditioning of the nictitating membrane response of the rabbit: II. Lesions of the cerebellar cortex, Exp. Brain Res., 60, 99, 10.1007/BF00237023 Zhao, 1999, The kinesthetic threat eyeblink: a new type of anticipatory eyeblink response, Brain Res., 839, 100, 10.1016/S0006-8993(99)01721-7