The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

American Association for the Advancement of Science (AAAS) - Tập 359 Số 6371 - Trang 104-108 - 2018
Vyara Matson1, Jessica Fessler1, Riyue Bao2,3, Tara Chongsuwat4, Yuanyuan Zha4, Maria‐Luisa Alegre4, Jason J. Luke4, Thomas F. Gajewski4,1
1Department of Pathology, University of Chicago, Chicago, IL 60637 USA
2Center for Research Informatics, University of Chicago, IL 60637, USA.
3Department of Pediatrics, University of Chicago, IL 60637, USA
4Department of Medicine, University of Chicago, Chicago, IL 60637, USA

Tóm tắt

Good bacteria help fight cancerResident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routyet al.show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade. They profiled samples from patients with lung and kidney cancers and found that nonresponding patients had low levels of the bacteriumAkkermansia muciniphila. Oral supplementation of the bacteria to antibiotic-treated mice restored the response to immunotherapy. Matsonet al.and Gopalakrishnanet al.studied melanoma patients receiving PD-1 blockade and found a greater abundance of “good” bacteria in the guts of responding patients. Nonresponders had an imbalance in gut flora composition, which correlated with impaired immune cell activity. Thus, maintaining healthy gut flora could help patients combat cancer.Science, this issue p.91, p.104, p.97; see also p.32

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Tài liệu tham khảo

10.1038/nature13954

10.1172/JCI91190

10.1038/cr.2016.149

10.1126/science.aac4255

10.1056/NEJMoa1200690

10.1056/NEJMoa1503093

10.1126/science.aan3706

10.1016/j.immuni.2016.09.009

10.1126/science.1240527

10.1126/science.aad1329

10.1126/science.1198469

10.1073/pnas.0909122107

10.1016/j.cell.2017.01.022

10.1126/science.aan4236

10.1038/nature14404

10.1158/2159-8290.CD-15-0283

10.1007/s00262-007-0407-z

10.1038/ismej.2012.8

10.1073/pnas.1000080107

10.1038/nmeth.f.303

10.1038/ismej.2011.139

10.1093/bioinformatics/btp636

10.1093/bioinformatics/btq461

10.1038/nmeth.2066

10.1038/nature11209

10.1128/AEM.01477-07

10.1128/AEM.07749-11

10.1099/mic.0.25975-0

10.1111/j.1574-6968.1998.tb13216.x

10.1053/j.gastro.2007.04.005

10.1128/JCM.01120-10

10.1111/j.1365-2672.2004.02409.x

10.1371/journal.pone.0003701

10.1128/AEM.01843-08

10.1111/j.1574-6968.2006.00629.x

10.1128/JCM.40.12.4423-4427.2002

10.1016/j.anaerobe.2011.03.004

10.1111/j.1365-2672.2008.03895.x

10.7554/eLife.00458

10.1128/IAI.05496-11

S. Andrews Q. C. Fast A quality control application for high throughput sequence data (Babraham Institute 2016); www.bioinformatics.babraham.ac.uk/projects/fastqc.

10.1038/nbt.3519

10.12688/f1000research.7563.1

H. Li Aligning sequence reads clone sequences and assembly contigs with BWA-MEM. arXiv:1303.3997v2 [q-bio.GN] (26 May 2013).

10.1093/bioinformatics/btv098

G. A. Van der Auwera, M. O. Carneiro, C. Hartl, R. Poplin, G. Del Angel, A. Levy-Moonshine, T. Jordan, K. Shakir, D. Roazen, J. Thibault, E. Banks, K. V. Garimella, D. Altshuler, S. Gabriel, M. A. DePristo, From FastQ data to high confidence variant calls: The Genome Analysis Toolkit best practices pipeline. Curr. Protoc. Bioinformatics 43, 1–33 (2013). 25431634

10.1038/nbt.2514

10.1038/nature15393

10.1038/nature11690

10.1038/nature19057

10.1093/nar/gkq603

10.1158/0008-5472.CAN-03-3259

Y. Benjamini, Y. Hochberg, Controlling the false discovery rate—A practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B Stat. Methodol. 57, 289–300 (1995).

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American Association for the Advancement of Science (AAAS)

Tập 359 Số 6371

104-108

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