Separation of Morphine Analgesia from Physical Dependence

American Association for the Advancement of Science (AAAS) - Tập 226 Số 4673 - Trang 462-464 - 1984
Geoffrey Ling1, Janet M. MacLeod1, Shay Lee1, Stephen H. Lockhart1, Gavril W. Pasternak1
1Laboratory of Neuro-Oncology and Laboratory of Biostatistics, Memorial Sloan-Kettering Cancer Center, and Departments of Neurology and Pharmacology, Cornell University Medical College, New York 10021

Tóm tắt

Intravenous infusion of morphine sulfate in rats for 24 hours produced marked opioid dependence, manifested by a series of well-documented signs appearing after injection of the opiate antagonist naloxone. Treatment of rats with naloxonazine significantly reduced the analgesia associated with the morphine infusions for more than 24 hours. Furthermore, 14 of 16 withdrawal signs observed in naloxonazine-treated rats were virtually identical to those in rats that received morphine alone. These results raise the possibility that different receptor mechanisms mediate morphine analgesia and many of the withdrawal signs associated with morphine dependence.

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Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 226 Số 4673

462-464

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