Metabolic age modelling: the lesson from centenarians

European Journal of Clinical Investigation - Tập 30 Số 10 - Trang 888-894 - 2000
Giuseppe Paolisso1, Michelangela Barbieri1, Massimiliano Bonafè2, Claudio Franceschi2
1II University of Naples, Naples - Italy
2University of Bologna, Bologna, Italy

Tóm tắt

Evolutionary theories of ageing, and data emerging from cellular and molecular biology of ageing, suggested that animals and humans capable of reaching an age close to the extreme limit of the life span should be equipped with a very efficient network of anti‐ageing mechanisms. Indeed several evidences have demonstrated that starting from young to very old subjects, ageing is associated with a progressive remodelling. Thus, a new paradigm, the remodelling theory of age, was proposed. This theory, focusing on the human immune system, suggested that immunosenescence is the net result of the continuous adaptation of the body to the deteriorative changes occurring over time. According to this hypothesis, body resources are continuously optimized, and immunosenescence must be considered a very dynamic process including both loss and gain. Whether the metabolic pathways and the endocrine functions are also part of the age remodelling is not investigated. The aim of this review is to focus on the age‐related changes in metabolic pathways and endocrine functions and to demonstrate that healthy centenarians (HC) represent the best living example of successful age‐remodelling in whom the age remodelling has occurred without problems. In order to design the clinical picture of such successful ageing, anthropometric, endocrine and metabolic characteristics of healthy centenarians (HC), compared with aged subject, have been outlined.

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Tài liệu tham khảo

10.1007/BF03323871

10.1016/0167-5699(95)80064-6

10.1016/0140-6736(92)91265-A

10.1210/edrv-16-6-686

Sansoni P, 1993, Lymphocytes subsets and natural killer cell activity in healthy old people and centenarians, Blood, 80, 2767, 10.1182/blood.V82.9.2767.2767

10.1172/JCI110908

10.1172/JCI110914

10.1016/0026-0495(92)90296-M

10.1210/jcem-60-1-13

10.2337/diab.45.7.947

10.1046/j.1365-2362.1999.00522.x

10.1161/01.ATV.14.4.518

10.1161/01.ATV.14.10.1641

10.2337/diacare.21.8.1236

Paolisso G, 1996, Glucose tolerance and insulin action in HC, Am J Physiol, 270, E890

The Italian Multicenter Study on Centenarians. I centenari in Italia. aspetti epidemiologici e clinico biologici. In:96th Meeting of the Italian Society of Internal Medicine Pozzi (Rome Italy) 1995. Rome: Italian Society of Internal Medicine;1995pp.117218.

10.1111/j.1532-5415.1997.tb03203.x

10.1042/CS19990101

10.1111/j.1532-5415.1996.tb03741.x

10.1002/(SICI)1096-9136(199708)14:3 <S45::AID-DIA444>3.3.CO;2-I

10.1016/S0026-0495(00)80082-7

10.1007/BF00418354

10.1016/S0008-6363(99)00367-3

10.1080/10715769900300841

10.1111/j.1532-5415.1998.tb02716.x

10.1097/00004872-199917010-00011

10.1002/ajhb.1310010408

10.1093/geronj/38.6.673

10.1093/ajcn/62.4.746

10.1152/jappl.1994.77.3.1122

10.1093/gerona/51A.4.B247

10.1055/s-2000-8847

10.1001/jama.1990.03440220053029

10.1056/NEJM199007053230101

10.1093/ajcn/68.4.975S

10.1093/jn/128.12.2627S

10.1002/j.1550-8528.1999.tb00404.x

10.1111/j.1532-5415.1999.tb07431.x

Cusi K, 1995, Treatment of NIDDM, IDDM and other insulin resistant states with IGF‐1. Physiological and clinical considerations, Diabetes Rev, 3, 206

Paolisso G, 1997, Serum levels of insulin like growth factor ‐1 (IGF‐1) and IGF‐binding protein 3 in HC. relationship with plasma leptin and lipid concentration, insulin action and cognitive function, J Clin Endocrinol Metab, 82, 2204, 10.1210/jcem.82.7.4087

10.1038/372425a0

10.1056/NEJM199602013340503

10.1016/S0006-2952(98)00246-9

10.1016/S0026-0495(97)90231-6

10.1111/j.1399-0039.1982.tb01436.x

10.1038/ng0194-29

10.1038/sj.ejhg.5200222

Yashin AI, 1998, Combining genetic demographic information in population studies of aging and longevity, J Epidem Biostatistics, 3, 289

10.1017/S0003480098006757

Snieder H, 1997, The age dependency of gene expression for plasma lipids, lipoprotein and apolipoproteins, Am J Hum Genet, 60, 638

Goldestain JL, 1989, Familial hypercholesterolemia, The Metabolic Basis Inherited Disease, 6, 1215

10.1111/j.1399-0004.1994.tb03998.x

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European Journal of Clinical Investigation

Tập 30 Số 10

888-894

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