Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells

Roulland, 2011, Early steps of follicular lymphoma pathogenesis., Adv Immunol, 111, 1, 10.1016/B978-0-12-385991-4.00001-5 Morin, 2011, Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma., Nature, 476, 298, 10.1038/nature10351 Scott, 2014, The tumour microenvironment in B cell lymphomas., Nat Rev Cancer, 14, 517, 10.1038/nrc3774 Coelho, 2010, Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins., Proc Natl Acad Sci USA, 107, 18587, 10.1073/pnas.1009388107 Radcliffe, 2007, Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor., J Biol Chem, 282, 7405, 10.1074/jbc.M602690200 Zabalegui, 2004, Acquired potential N-glycosylation sites within the tumor-specific immunoglobulin heavy chains of B-cell malignancies., Haematologica, 89, 541 Zhu, 2002, Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma., Blood, 99, 2562, 10.1182/blood.V99.7.2562 McCann, 2008, Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma., Mol Immunol, 45, 1567, 10.1016/j.molimm.2007.10.009 Zhu, 2003, Incidence of potential glycosylation sites in immunoglobulin variable regions distinguishes between subsets of Burkitt’s lymphoma and mucosa-associated lymphoid tissue lymphoma., Br J Haematol, 120, 217, 10.1046/j.1365-2141.2003.04064.x Arnold, 2005, Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin., J Biol Chem, 280, 29080, 10.1074/jbc.M504528200 McGreal, 2004, Divergent roles for C-type lectins expressed by cells of the innate immune system., Mol Immunol, 41, 1109, 10.1016/j.molimm.2004.06.013 van den Berg, 2012, An evolutionary perspective on C-type lectins in infection and immunity., Ann N Y Acad Sci, 1253, 149, 10.1111/j.1749-6632.2011.06392.x Greenman, 1991, Characterization of a new monoclonal anti-Fc gamma RII antibody, AT10, and its incorporation into a bispecific F(ab’)2 derivative for recruitment of cytotoxic effectors., Mol Immunol, 28, 1243, 10.1016/0161-5890(91)90011-8 Krysov, 2010, Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo., Blood, 115, 4198, 10.1182/blood-2009-12-254847 Irish, 2010, B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression., Proc Natl Acad Sci USA, 107, 12747, 10.1073/pnas.1002057107 Mockridge, 2007, Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status., Blood, 109, 4424, 10.1182/blood-2006-11-056648 Vlad, 2009, Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease., Cancer Res, 69, 6387, 10.1158/0008-5472.CAN-08-4750 Burger, 2010, Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): from understanding the basics towards therapeutic targeting., Semin Cancer Biol, 20, 424, 10.1016/j.semcancer.2010.09.005 Pepper, 2015, Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition., Leukemia, 29, 744, 10.1038/leu.2014.308 Coelho, 2013, Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function., Blood, 122, 2664, 10.1182/blood-2013-02-485425 Victora, 2014, Clonal and cellular dynamics in germinal centers., Curr Opin Immunol, 28, 90, 10.1016/j.coi.2014.02.010 Amé-Thomas, 2014, The yin and the yang of follicular lymphoma cell niches: role of microenvironment heterogeneity and plasticity., Semin Cancer Biol, 24, 23, 10.1016/j.semcancer.2013.08.001 Farinha, 2005, Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL)., Blood, 106, 2169, 10.1182/blood-2005-04-1565 Byers, 2008, Clinical quantitation of immune signature in follicular lymphoma by RT-PCR-based gene expression profiling., Blood, 111, 4764, 10.1182/blood-2007-10-115915 Mantovani, 2015, The interaction of anticancer therapies with tumor-associated macrophages., J Exp Med, 212, 435, 10.1084/jem.20150295 Stevenson, 2012, Follicular lymphoma and the immune system: from pathogenesis to antibody therapy., Blood, 119, 3659, 10.1182/blood-2011-11-367730 Mamessier, 2015, Contiguous follicular lymphoma and follicular lymphoma in situ harboring N-Glycosylated sites., Haematologica, 100, e155, 10.3324/haematol.2014.115782 Rosén, 2010, Antigens in chronic lymphocytic leukemia--implications for cell origin and leukemogenesis., Semin Cancer Biol, 20, 400, 10.1016/j.semcancer.2010.09.004 Tolar, 2014, Force generation in B-cell synapses: mechanisms coupling B-cell receptor binding to antigen internalization and affinity discrimination., Adv Immunol, 123, 69, 10.1016/B978-0-12-800266-7.00002-9 Soilleux, 2002, Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro., J Leukoc Biol, 71, 445, 10.1189/jlb.71.3.445 Schneider, 2015, Lectins from opportunistic bacteria interact with acquired variable region glycans of surface Ig in follicular lymphoma., Blood, 125, 3287, 10.1182/blood-2014-11-609404 Marth, 2008, Mammalian glycosylation in immunity., Nat Rev Immunol, 8, 874, 10.1038/nri2417 Dennis, 2009, Adaptive regulation at the cell surface by N-glycosylation., Traffic, 10, 1569, 10.1111/j.1600-0854.2009.00981.x Doores, 2010, Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens., Proc Natl Acad Sci USA, 107, 13800, 10.1073/pnas.1006498107 Gordon-Alonso, 2014, Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins., OncoImmunology, 3, e28783, 10.4161/onci.28783