Block of Ca 2+ Wave and Ca 2+ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs

American Association for the Advancement of Science (AAAS) - Tập 257 Số 5067 - Trang 251-255 - 1992
Shun-ichi Miyazaki1, Michisuke Yuzaki2, Ken NAKADA1, Hideki Shirakawa1, Setsuko Nakanishi3, Shinji Nakade3, Katsuhiko Mikoshiba4
1Department of Physiology, Tokyo Women's Medical College, Tokyo 162, Japan
2Department of Biochemistry, Jichi Medical School, Tochigi-ken, 329-04, Japan
3Division of Regulation of Macromolecular Function, Institute for Protein Research, Osaka University, Suita 565 Japan
4Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, 108, Japan

Tóm tắt

The concentration of cytoplasmic free calcium (Ca 2+ ) increases in various stimulated cells in a wave (Ca 2+ wave) and in periodic transients (Ca 2+ oscillations). These phenomena are explained by inositol 1,4,5-trisphosphate (IP 3 )-induced Ca 2+ release (IICR) and Ca 2+ -induced Ca 2+ release (CICR) from separate intracellular stores, but decisive evidence is lacking. A monoclonal antibody to the IP 3 receptor inhibited both IICR and CICR upon injection of IP 3 and Ca 2+ into hamster eggs, respectively. The antibody completely blocked sperm-induced Ca 2+ waves and Ca 2+ oscillations. The results indicate that Ca 2+ release in fertilized hamster eggs is mediated solely by the IP 3 receptor, and Ca 2+ -sensitized IICR, but not CICR, generates Ca 2+ waves and Ca 2+ oscillations.

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American Association for the Advancement of Science (AAAS)

Tập 257 Số 5067

251-255

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