Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics

American Association for the Advancement of Science (AAAS) - Tập 286 Số 5439 - Trang 487-491 - 1999
William E. Evans1, Mary V. Relling1
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA, and Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN 38105, USA.

Tóm tắt

Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution.

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Supported in part by grants NIH R37 CA36401 RO1 CA51001 and RO1 CA78224; Cancer Center support grant CA21765; a Center of Excellence grant from the state of Tennessee; and the American Lebanese Syrian Associated Charities (ALSAC). We thank J. Johnson M. Kastan C. Naeve D. Roden E. Schuetz J. Schuetz and E. Tuomanen for helpful suggestions; L. Rawlinson for artistic contributions to Figs. 1 and 3; and S. Davis G. McDugle and F. Munn for help in preparing the manuscript.

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American Association for the Advancement of Science (AAAS)

Tập 286 Số 5439

487-491

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