Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Bioorganic & Medicinal Chemistry Letters - Tập 20 - Trang 3387-3393 - 2010
Jian-kang Jiang1, Matthew B. Boxer1, Matthew G. Vander Heiden2,3,4, Min Shen1, Amanda P. Skoumbourdis1, Noel Southall1, Henrike Veith1, William Leister1, Christopher P. Austin1, Hee Won Park5,6, James Inglese1, Lewis C. Cantley3,7, Douglas S. Auld1, Craig J. Thomas1
1NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA
2Koch Institute at MIT, Cambridge, MA 02139, USA
3Dana-Farber Cancer Institute, Boston, MA 02115 USA
4Department of Systems Biology, Harvard Medical School, Boston, MA, 02115, USA
5Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada M5G 1L5
6Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
7Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115 USA

Tài liệu tham khảo

Devita, 2005

Vander Heiden, 2009, Science, 324, 1029, 10.1126/science.1160809

Warburg, 1956, Science, 123, 309, 10.1126/science.123.3191.309

Warburg, 1956, Science, 124, 269, 10.1126/science.124.3215.269

Mazurek, 2005, Semin. Cancer Biol., 15, 300, 10.1016/j.semcancer.2005.04.009

Takenaka, 1991, Eur. J. Biochem., 198, 101, 10.1111/j.1432-1033.1991.tb15991.x

Takenaka, 1996, Eur. J. Biochem., 235, 366, 10.1111/j.1432-1033.1996.00366.x

Noguchi, 1986, J. Biol. Chem., 261, 13807, 10.1016/S0021-9258(18)67091-7

Yamada, 1999, Biochem. Biophys. Res. Commun., 256, 257, 10.1006/bbrc.1999.0228

Reinacher, 1981, Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol., 37, 79, 10.1007/BF02892557

Noguchi, 1987, J. Biol. Chem., 262, 14366, 10.1016/S0021-9258(18)47947-1

Staal, 1991, 313

Steinberg, 1999, Virchows Arch., 434, 313, 10.1007/s004280050330

DeBerardinis, 2008, Cell Metab., 7, 11, 10.1016/j.cmet.2007.10.002

DeBerardinis, 2008, Curr. Opin. Genet. Dev., 18, 54, 10.1016/j.gde.2008.02.003

Eigenbrodt, 1997, Anticancer Res., 17, 3153

Dombrauckas, 2005, Biochemistry, 44, 9417, 10.1021/bi0474923

Christofk, 2008, Nature, 452, 230, 10.1038/nature06734

Christofk, 2008, Nature, 452, 181, 10.1038/nature06667

Boxer, 2010, J. Med. Chem., 53, 1048, 10.1021/jm901577g

Fan, 2007, Assay Drug Dev. Technol., 5, 127, 10.1089/adt.2006.053

Singh, 2004, Assay Drug Dev. Technol., 2, 161, 10.1089/154065804323056503

Inglese, 2006, Proc. Natl. Acad. Sci. U.S.A., 103, 11473, 10.1073/pnas.0604348103

Eras, 1984, J. Heterocycl. Chem., 21, 215, 10.1002/jhet.5570210143

Bennasar, 2005, J. Org. Chem., 70, 9077, 10.1021/jo0514974

Gale, 1964, J. Org. Chem., 29, 2160, 10.1021/jo01031a012

Klapars, 2001, J. Am. Chem. Soc., 123, 7727, 10.1021/ja016226z

Wu, 2008, Faming Zhuanli Shenqing Gongkai Shuomingshu, CN, 10035041

Wang, 2006, Org. Lett., 8, 305, 10.1021/ol052704p

dit Chabert, 2007, Bioorg. Med. Chem., 15, 4482, 10.1016/j.bmc.2007.04.023

Frère, 2003, J. Org. Chem., 68, 7254, 10.1021/jo034319o

Marques, 2002, Helv. Chim. Acta, 85, 4485, 10.1002/hlca.200290024

Pandey, 2002, J. Med. Chem., 45, 3772, 10.1021/jm020143r

Aqueous solubility was assessed at a pH of 7.4 at room temperature from stock DMSO solutions. http://www.analiza.com/.

Hannaert, 2002, FEBS Lett., 514, 255, 10.1016/S0014-5793(02)02374-8

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Bioorganic & Medicinal Chemistry Letters

Tập 20

3387-3393

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