Brick by brick: metabolism and tumor cell growth

Current Opinion in Genetics & Development - Tập 18 - Trang 54-61 - 2008
Ralph J DeBerardinis1,2,3, Nabil Sayed1,2, Dara Ditsworth1, Craig B Thompson1
1Department of Cancer Biology, Abramson Cancer Center and Abramson Family Cancer Research Institute, University of Pennsylvania, 1600 Penn Tower, 3400 Spruce Street, Philadelphia, PA 19104, United States
2Department of Pediatrics, The Children's Hospital of Philadelphia, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States
3Department of Pediatrics, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States

Tài liệu tham khảo

Warburg, 1925, Uber den Stoffwechsel der Carcinomzelle, Klin Wochenschr Berl, 4, 534, 10.1007/BF01726151 Warburg, 1956, On the origin of cancer cells, Science, 123, 309, 10.1126/science.123.3191.309 Kim, 2006, Cancer's molecular sweet tooth and the Warburg effect, Cancer Res, 66, 8927, 10.1158/0008-5472.CAN-06-1501 Wang, 1976, Aerobic glycolysis during lymphocyte proliferation, Nature, 261, 702, 10.1038/261702a0 Bauer, 2004, Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand, FASEB J, 18, 1303, 10.1096/fj.03-1001fje Ramanathan, 2005, Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements, Proc Natl Acad Sci U S A, 102, 5992, 10.1073/pnas.0502267102 Brand, 1985, Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism, Biochem J, 228, 353, 10.1042/bj2280353 DeBerardinis, 2008, The biology of cancer: metabolic reprogramming fuels cell growth and proliferation, Cell Metab, 7, 11, 10.1016/j.cmet.2007.10.002 Dang, 1997, Oncogenes in tumor metabolism, tumorigenesis, and apoptosis, J Bioenerg Biomembr, 29, 345, 10.1023/A:1022446730452 Rashid, 1997, Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia, Am J Pathol, 150, 201 Bensaad, 2006, TIGAR, a p53-inducible regulator of glycolysis and apoptosis, Cell, 126, 107, 10.1016/j.cell.2006.05.036 Bensaad, 2007, p53: new roles in metabolism, Trends Cell Biol, 17, 286, 10.1016/j.tcb.2007.04.004 Kondoh, 2005, Glycolytic enzymes can modulate cellular life span, Cancer Res, 65, 177, 10.1158/0008-5472.177.65.1 Matoba, 2006, p53 regulates mitochondrial respiration, Science, 312, 1650, 10.1126/science.1126863 Mazurek, 2005, Pyruvate kinase type M2 and its role in tumor growth and spreading, Semin Cancer Biol, 15, 300, 10.1016/j.semcancer.2005.04.009 Netzker, 1992, Cell cycle-associated expression of M2-type isozyme of pyruvate kinase in proliferating rat thymocytes, J Biol Chem, 267, 6421, 10.1016/S0021-9258(18)42712-3 Altenberg, 2004, Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes, Genomics, 84, 1014, 10.1016/j.ygeno.2004.08.010 Boros, 1997, Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation, Cancer Res, 57, 4242 Forbes, 2006, Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis, Metab Eng, 8, 639, 10.1016/j.ymben.2006.06.005 Boros, 2002, Metabolic profiling of cell growth and death in cancer: applications in drug discovery, Drug Discov Today, 7, 364, 10.1016/S1359-6446(02)02179-7 Cocco, 1998, Mortality in a cohort of men expressing the glucose-6-phosphate dehydrogenase deficiency, Blood, 91, 706, 10.1182/blood.V91.2.706 Cocco, 1989, Glucose-6-phosphate dehydrogenase deficiency and cancer in a Sardinian male population: a case–control study, Carcinogenesis, 10, 813, 10.1093/carcin/10.5.813 Comin-Anduix, 2001, The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study, Eur J Biochem, 268, 4177, 10.1046/j.1432-1327.2001.02329.x Langbein, 2006, Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted, Br J Cancer, 94, 578, 10.1038/sj.bjc.6602962 Krockenberger, 2007, Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases, Int J Gynecol Cancer, 17, 101, 10.1111/j.1525-1438.2007.00799.x Stryer, 2002, The calvin cycle and the pentose phosphate pathway, 568 Swinnen, 2006, Increased lipogenesis in cancer cells: new players, novel targets, Curr Opin Clin Nutr Metab Care, 9, 358, 10.1097/01.mco.0000232894.28674.30 Kannan, 1980, Dietary control of lipogenesis in vivo in host tissues and tumors of mice bearing Ehrlich ascites carcinoma, Cancer Res, 40, 4606 Ookhtens, 1984, Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor, Am J Physiol, 247, R146 Kuhajda, 1994, Fatty acid synthesis: a potential selective target for antineoplastic therapy, Proc Natl Acad Sci U S A, 91, 6379, 10.1073/pnas.91.14.6379 Pizer, 1996, Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer, Cancer Res, 56, 1189 Hatzivassiliou, 2005, ATP citrate lyase inhibition can suppress tumor cell growth, Cancer Cell, 8, 311, 10.1016/j.ccr.2005.09.008 Brusselmans, 2005, RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells, Cancer Res, 65, 6719, 10.1158/0008-5472.CAN-05-0571 Chajes, 2006, Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival, Cancer Res, 66, 5287, 10.1158/0008-5472.CAN-05-1489 Samuels, 2004, High frequency of mutations of the PIK3CA gene in human cancers, Science, 304, 554, 10.1126/science.1096502 Samuels, 2006, Oncogenic PI3K and its role in cancer, Curr Opin Oncol, 18, 77, 10.1097/01.cco.0000198021.99347.b9 Porstmann, 2005, PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP, Oncogene, 24, 6465, 10.1038/sj.onc.1208802 Chang, 2005, KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells, J Lipid Res, 46, 2624, 10.1194/jlr.M500154-JLR200 Edinger, 2002, Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake, Mol Biol Cell, 13, 2276, 10.1091/mbc.01-12-0584 Wieman, 2007, Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking, Mol Biol Cell, 18, 1437, 10.1091/mbc.E06-07-0593 Buzzai, 2005, The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation, Oncogene, 24, 4165, 10.1038/sj.onc.1208622 DeBerardinis, 2006, Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth, J Biol Chem, 281, 37372, 10.1074/jbc.M608372200 Lum, 2007, The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis, Genes Dev, 21, 1037, 10.1101/gad.1529107 Chang, 1973, Enzymatic and immunological studies on pyruvate carboxylase in livers and liver tumors, Cancer Res, 33, 2034 Hammond, 1978, Activities of key gluconeogenic enzymes and glycogen synthase in rat and human livers, hepatomas, and hepatoma cell cultures, Cancer Res, 38, 1317 Brand, 1992, A 13C NMR study on fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells, Biochimie, 74, 941, 10.1016/0300-9084(92)90078-S DeBerardinis, 2007, Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis, Proc Natl Acad Sci U S A, 104, 19345, 10.1073/pnas.0709747104 Amemiya-Kudo, 2002, Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes, J Lipid Res, 43, 1220, 10.1194/jlr.M100417-JLR200 Eagle, 1956, The growth response of mammalian cells in tissue culture to l-glutamine and l-glutamic acid, J Biol Chem, 218, 607, 10.1016/S0021-9258(18)65826-0 Reitzer, 1979, Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells, J Biol Chem, 254, 2669, 10.1016/S0021-9258(17)30124-2 Turner, 2003, Glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas, Biochem J, 370, 403, 10.1042/bj20021360 Perez-Gomez, 2005, Co-expression of glutaminase K and L isoenzymes in human tumour cells, Biochem J, 386, 535, 10.1042/BJ20040996 Matsuno, 1989, Glutamine synthetase and glutaminase activities in various hepatoma cells, Biochem Int, 19, 219 Matsuno, 1992, Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma, Cancer Res, 52, 1192 Aledo, 1994, Phosphate-activated glutaminase expression during tumor development, FEBS Lett, 341, 39, 10.1016/0014-5793(94)80236-X Ahluwalia, 1990, Metabolism and action of amino acid analog anti-cancer agents, Pharmacol Ther, 46, 243, 10.1016/0163-7258(90)90094-I Lobo, 2000, Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells, Biochem J, 348, 257, 10.1042/0264-6021:3480257 Elgadi, 1999, Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing, Physiol Genomics, 1, 51, 10.1152/physiolgenomics.1999.1.2.51 Porter, 2002, Complexity and species variation of the kidney-type glutaminase gene, Physiol Genomics, 9, 157, 10.1152/physiolgenomics.00017.2002 Portais, 1996, Glucose and glutamine metabolism in C6 glioma cells studied by carbon 13 NMR, Biochimie, 78, 155, 10.1016/0300-9084(96)89500-9 Yuneva, 2007, Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells, J Cell Biol, 178, 93, 10.1083/jcb.200703099 Christofk, 2008, The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumor growth, Nature, 452, 230, 10.1038/nature06734 Christofk, 2008, Pyruvate kinase M2 is a phosphotyrosine-binding protein, Nature, 452, 181, 10.1038/nature06667