Limitations in Translating Animal Studies to Humans in Cardiovascular Disease

Journal of Cardiovascular Translational Research - Tập 9 - Trang 165-166 - 2016
Sean Lal1, Amy Li1, Cristobal dos Remedios1
1Discipline of Anatomy & Histology, Bosch Institute, University of Sydney, Sydney, Australia

Tài liệu tham khảo

Goodman J, Chandna A, and Roe K. Trends in animal use at US research facilities. J Med Ethics doi:10.1136/medethics-2014-102404 Laboratory Animals – Species in Research. National Association of Biomedical Research 2014. http://www.nabr.org/biomedical-research/laboratory-animals/species-in-research/ Pfeffer, J., & Pfeffer, M. (1988). Angiotensin converting enzyme inhibition and ventricular remodeling in heart failure. American Journal of Medicine, 84(3), 37–44. Pfeffer, M., Braunwald, E., Moye, L., Basta, L., Brown, E., et al. (1992). Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction—results of the Survival and Ventricular Enlargement Trial. New England Journal of Medicine, 327, 669–677. Von Lueder, T., Wang, B., Kompa, A., et al. (2015). Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. Circulation Heart Failure, 8, 71–8. No authors listed (2013). Of Men, Not Mice. Nature Medicine, 19(4), 379. doi:10.1038/nm.3163. Sawinski, D., & Maltzman, J. S. (2015). Do mice need an order of fries to be relevant for transplant studies? American Journal of Transplantation, 15, 2282–4. McNally, E., Kraft, R., Bravo-Zehnder, M., Taylor, D., & Leinwand, L. (1989). Full-length rat alpha and beta cardiac myosin heavy chain sequences: comparisons suggest a molecular basis for functional differences. Journal of Molecular Biology, 210(3), 665–71. Milani-Nejad, N., & Janssen, M. (2014). Small and large animal models in cardiac contraction research: advantages and disadvantages. Pharmacology & Therapeutics, 141(3), 235–49. Collins, F., & Varmus, H. (2015). A new initiative on precision medicine. New England Journal of Medicine, 372, 793–795. Mak, I., Evaniew, N., & Ghert, M. (2014). Lost in translation: animal models and clinical trials in cancer treatment. American Journal of Translational Research, 6(2), 114–118.