RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα
Tóm tắt
The signal to move or proliferate diverges at RAF1.
Từ khóa
Tài liệu tham khảo
C. Rommel, G. Radziwill, J. Lovrić, J. Noeldeke, T. Heinicke, D. Jones, A. Aitken, K. Moelling, Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf- 1. Oncogene 12, 609–619 (1996).
S. Corbalan-Garcia, K. R. Degenhardt, D. Bar-Sagi, Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation. Oncogene 12, 1063–1068 (1996).
L. Buday, P. H. Warne, J. Downward, Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos. Oncogene 11, 1327–1331 (1995).