Chemical constituents and their bioactivities from truffle Hysterangium inflatum

Journal of Food Measurement and Characterization - Tập 15 Số 5 - Trang 4181-4189 - 2021
Taş, Meltem1, Küçükaydın, Selçuk2, Tel-Çayan, Gülsen3, Duru, Mehmet Emin1, Öztürk, Mehmet1, Türk, Mustafa4
1Department of Chemistry, Faculty of Science, Muğla Sıtkı Koçman University, Muğla, Turkey
2Department of Medical Services and Techniques, Köyceğiz Vocational School of Health Services, Muğla Sıtkı Koçman University, Köyceğiz, Turkey
3Department of Chemistry and Chemical Processing Technologies, Muğla Vocational School, Muğla Sıtkı Koçman University, Muğla, Turkey
4Department of Bioengineering, Faculty of Engineering and Architecture, Kirikkale University, Kirikkale, Turkey

Tóm tắt

Hysterangium inflatum is a truffle that grows naturally in the roots of Eucalyptus sp. and is distributed along the Mediterranean and Aegean coasts. Chemical investigation of the H. inflatum enabled to isolate of a new cerebroside, hysteroside (1), and seven known compounds namely, psyllic acid (2), brassicasterol (3), ergosterol (4), ergosterol d (5), ergosterol peroxide (6), ergosta-7,9,22-triene-3-O-β-d-glucoside (7) and mannitol (8). IR, NMR, MS techniques were used for structural elucidation and supported with literature data. Antioxidant, cholinesterase, urease, and tyrosinase inhibitory and cytotoxic activities on MCF-7 breast, H-1299 lung cancer cells, and murine fibroblast (L929) non-cancerous cells of extracts and isolated compounds from H. inflatum were analyzed. All the isolated compounds, except compounds 2 and 8, displayed considerable cytotoxic activities against MCF-7 and H-1299 cancer cells. Compounds 1 (IC50: 18.11 µg/mL) and 5 (IC50: 24.93 µg/mL) were the most effective against MCF-7, while compounds 6 (IC50: 27.61 µg/mL), 1 (IC50: 36.20 µg/mL) and 5 (IC50: 38.62 µg/mL) showed most potent toxicity against H-1299 and the extracts and compounds have no toxic effect on L929. Among the extracts, the methanol extract displayed the best antioxidant activity in all assays. Compound 1 exhibited highest enzyme inhibition activities with value of 58.71%, 52.84%, 45.37%, and 35.63%, against urease, tyrosinase, butrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzymes at 100 µg/mL concentration, among the isolated compounds. These results support that H. inflatum is a steroid-rich truffle and might be a potential source, especially for ergostane type steroids.

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Journal of Food Measurement and Characterization

Tập 15 Số 5

4181-4189

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