A Manual for Assessing Health Practices and Designing Practice Guidelines. Philadelphia, PA: American College of Physicians; 1996.
1995, Gastroenterology, 108, 925, 10.1016/0016-5085(95)90469-7
Methodology Manual for ACC/AHA Guideline Writing Committees (April 2006). Available at: http://www.americanheart.org/presenter.jhtml?identifier_3039683. Accessed July 2007.
Shiffman, 2003, Ann Intern Med, 139, 493, 10.7326/0003-4819-139-6-200309160-00013
Wilson, 1912, Brain, 34, 295, 10.1093/brain/34.4.295
Bearn, 1960, Ann Hum Genet, 24, 33, 10.1111/j.1469-1809.1959.tb01713.x
Walshe, 2006, Mov Disord, 21, 142, 10.1002/mds.20694
Bull, 1993, Nat Genet, 5, 327, 10.1038/ng1293-327
Tanzi, 1993, Nat Genet, 5, 344, 10.1038/ng1293-344
Yamaguchi, 1993, Biochem Biophys Res Commun, 197, 271, 10.1006/bbrc.1993.2471
Holtzman, 1970, J Biol Chem, 245, 2354, 10.1016/S0021-9258(18)63159-X
Frydman, 1990, J Gastroenterol Hepatol, 5, 483, 10.1111/j.1440-1746.1990.tb01427.x
Cumings, 1951, Brain, 74, 10, 10.1093/brain/74.1.10
Denny-Brown, 1951, New Engl J Med, 245, 917, 10.1056/NEJM195112132452401
Walshe, 1956, Lancet, 25, 10.1016/S0140-6736(56)91859-1
Fleischer, 1912, Deutsch Z Nerven Heilk, 44, 179, 10.1007/BF01630499
Scheinberg, 1952, Science, 116, 484, 10.1126/science.116.3018.484
Sternlieb, 1990, HEPATOLOGY, 12, 1234, 10.1002/hep.1840120526
Steindl, 1997, Gastroenterology, 113, 212, 10.1016/S0016-5085(97)70097-0
Ferenci, 2003, Liver Int, 23, 139, 10.1034/j.1600-0676.2003.00824.x
Koppikar, 2005, Liver Int, 25, 680, 10.1111/j.1478-3231.2005.01072.x
The liver in Wilson's disease. In: , eds. Diseases of the Liver. 6th ed. Philadelphia, PA: J B Lippincott; 1987: 1037–1050.
Saito, 1987, Eur J Pediatr, 146, 261, 10.1007/BF00716470
Scott, 1978, Gastroenterology, 74, 645, 10.1016/0016-5085(78)90238-X
Schilsky, 1991, Gastroenterology, 100, 762, 10.1016/0016-5085(91)80023-3
Milkiewicz, 2000, J Gastroenterol Hepatol, 15, 570, 10.1046/j.1440-1746.2000.02158.x
Azizi, 1989, Eur J Pediatr, 148, 548, 10.1007/BF00441555
Nakada, 1994, J Urol, 152, 978, 10.1016/S0022-5347(17)32635-6
Chu, 1996, Nephron, 73, 477, 10.1159/000189114
Golding, 1977, Ann Rheum Dis, 36, 99, 10.1136/ard.36.2.99
Factor, 1982, Virchows Arch Pathol Anat, 397, 301, 10.1007/BF00496571
Kuan, 1987, Chest, 91, 579, 10.1378/chest.91.4.579
Hlubocka, 2002, J Inherit Metab Dis, 25, 269, 10.1023/A:1016546223327
Weizman, 1988, J Pediatr Gastroenterol Nutr, 7, 931, 10.1097/00005176-198811000-00024
Carpenter, 1983, N Engl J Med, 309, 873, 10.1056/NEJM198310133091501
Walshe, 1977, Q J Med, 46, 73
Klee, 1979, Lancet, 2, 423, 10.1016/S0140-6736(79)90440-9
Kaushansky, 1987, Fertil Steril, 47, 270, 10.1016/S0015-0282(16)50004-1
Tarnacka, 2000, Acta Neurol Scand, 101, 395, 10.1034/j.1600-0404.2000.90140a.x
Iorio, 2003, J Pediatr Gastroenterol Nutr, 36, 637, 10.1097/00005176-200305000-00009
Beyersdorff, 2006, Scand J Gastroenterol, 41, 496, 10.1080/00365520500389453
Mak, 2006, Hong Kong Med J, 12, 154
Lo Curto, 2006, J Pediatr, 148, 141, 10.1016/j.jpeds.2005.07.040
Caprai, 2006, J Pediatr, 148, 138, 10.1016/j.jpeds.2005.07.036
Wilson, 2000, J Pediatr, 137, 719, 10.1067/mpd.2000.108569
Kalach, 1993, Can J Gastroenterol, 7, 610, 10.1155/1993/508674
Ala, 2005, HEPATOLOGY, 41, 668, 10.1002/hep.20601
Perri, 2005, HEPATOLOGY, 42, 974, 10.1002/hep.20893
Fleming, 1977, Ann Intern Med, 86, 285, 10.7326/0003-4819-86-3-285
Frommer, 1977, Gastroenterology, 72, 1331, 10.1016/S0016-5085(77)80038-3
Tauber, 1993, Cornea, 12, 74, 10.1097/00003226-199301000-00013
Dunn, 1987, J Pediatr, 110, 771, 10.1016/S0022-3476(87)80022-7
Gow, 2000, Gut, 46, 415, 10.1136/gut.46.3.415
Emre, 2001, Transplantation, 72, 1232, 10.1097/00007890-200110150-00008
Medici, 2006, J Clin Gastroenterol, 40, 936, 10.1097/01.mcg.0000225670.91722.59
Merle, 2007, Gut, 56, 115, 10.1136/gut.2005.087262
Martins da Costa, 1992, HEPATOLOGY, 15, 609, 10.1002/hep.1840150410
Giacchino, 1997, Ital J Gastroenterol Hepatol, 29, 155
Sanchez-Albisua, 1999, J Pediatr Gastroenterol Nutr, 28, 186, 10.1097/00005176-199902000-00018
Demirkiran, 1996, Neurology, 46, 1040, 10.1212/WNL.46.4.1040
Cairns, 1969, Br Med J, 3, 95, 10.1136/bmj.3.5662.95
Schilsky, 1994, HEPATOLOGY, 19, 583, 10.1002/hep.1840190307
Esmaeli, 1996, Cornea, 15, 582, 10.1097/00003226-199611000-00008
Shiva, 2006, Nat Chem Biol, 2, 486, 10.1038/nchembio813
, , . Measurement of the concentration of ceruloplasmin by determination of its oxidase activity. In: , eds. Laboratory Diagnosis of Liver Diseases. St. Louis, MO: Warren H. Green; 1968: 193–195.
Schosinsky, 1974, Clin Chem, 20, 1556, 10.1093/clinchem/20.12.1556
Gnanou, 2006, Indian J Med Sci, 60, 371, 10.4103/0019-5359.27221
Walshe, 2005, Mov Disord, 20, 1658, 10.1002/mds.20628
Fuhrman, 2001, J Parenter Enteral Nutr, 24, 361, 10.1177/0148607100024006361
Menkes, 1999, Eur J Paediatr Neurol, 3, 147, 10.1016/S1090-3798(99)90048-X
Edwards, 1979, Clin Genet, 15, 311, 10.1111/j.1399-0004.1979.tb01740.x
Xu, 2004, Ann N Y Acad Sci, 1012, 299, 10.1196/annals.1306.024
Cauza, 1997, J Hepatol, 27, 358, 10.1016/S0168-8278(97)80182-1
Perman, 1979, J Pediatr, 94, 564, 10.1016/S0022-3476(79)80011-6
. Wilson's Disease. Philadelphia, PA: W B Saunders; 1984.
Walshe, 1989, Q J Med, 70, 253
Lau, 1990, Q J Med, 75, 597
Roberts, 1998, Baillières Clin Gastroenterol, 12, 237, 10.1016/S0950-3528(98)90133-6
Gaffney, 2000, J Clin Pathol, 53, 807, 10.1136/jcp.53.11.807
Tu, 1967, Metabolism, 16, 507, 10.1016/0026-0495(67)90079-0
Gross, 1985, Gastroenterology, 89, 272, 10.1016/0016-5085(85)90326-9
Garcia-Villarreal, 2000, HEPATOLOGY, 32, 1329, 10.1053/jhep.2000.20152
Frommer, 1981, Digestion, 21, 169, 10.1159/000198559
LaRusso, 1976, Gastroenterology, 70, 653, 10.1016/S0016-5085(76)80249-1
Muller, 2007, J Hepatol, 47, 270, 10.1016/j.jhep.2007.03.011
Dhawan, 2005, Liver Transpl, 11, 441, 10.1002/lt.20352
Roberts, 2004, J Pediatr Gastroenterol Nutr, 39, a128, 10.1097/00005176-200406001-00307
Ferenci, 2005, Clin Gastroenterol Hepatol, 3, 811, 10.1016/S1542-3565(05)00181-3
Song, 2000, Clin Biochem, 33, 589, 10.1016/S0009-9120(00)00164-8
Lyon, 1995, Clin Sci (Lond), 88, 727, 10.1042/cs0880727
Alt, 1990, Int Rev Exp Pathol, 31, 165, 10.1016/B978-0-12-364931-7.50011-2
Ludwig, 1994, Am J Clin Pathol, 102, 443, 10.1093/ajcp/102.4.443
Langner, 2004, Virchows Arch, 445, 111
Stromeyer, 1980, Am J Clin Pathol, 73, 12, 10.1093/ajcp/73.1.12
Strand, 1998, Nat Med, 4, 588, 10.1038/nm0598-588
Goldfischer, 1968, Am J Pathol, 53, 883
Geller, 2000, Mod Pathol, 13, 184a
Sternlieb, 1968, Gastroenterology, 55, 354, 10.1016/S0016-5085(19)34045-4
Feldmann, 1969, Biol Gastroenterol, 2, 137
Sternlieb, 1992, HEPATOLOGY, 16, 728, 10.1002/hep.1840160319
, , . The Liver. An Atlas and Text of Ultrastructural Pathology. New York, NY: Raven Press; 1987.
Sternlieb, 1976, Gastroenterology, 71, 457, 10.1016/S0016-5085(76)80455-6
Walshe, 2003, Q J Med, 96, 657, 10.1093/qjmed/hcg114
Iwadate, 2004, Intern Med, 43, 1042, 10.2169/internalmedicine.43.1042
Kumagi, 2004, J Gastroenterol, 39, 1165, 10.1007/s00535-004-1466-y
Kumagi, 2005, Intern Med, 44, 439, 10.2169/internalmedicine.44.439
Savas, 2006, Pediatr Transplant, 10, 639, 10.1111/j.1399-3046.2006.00562.x
Xu, 2007, Semin Liver Dis, 27, 122, 10.1055/s-2007-967203
Jung, 2005, Arch Neurol, 62, 1628, 10.1001/archneur.62.10.1628
Bhattacharya, 2002, Clin Auton Res, 12, 190, 10.1007/s10286-002-0017-y
Aisen, 1985, Radiology, 157, 137, 10.1148/radiology.157.1.4034959
van Wassenaer-van Hall, 1996, Radiology, 198, 531, 10.1148/radiology.198.2.8596862
Brewer, 1994, Arch Neurol, 51, 545, 10.1001/archneur.1994.00540180023009
Brewer, 1998, J Lab Clin Med, 132, 264, 10.1016/S0022-2143(98)90039-7
Thomas, 1995, Am J Hum Genet, 56, 1315
Maier-Dobersberger, 1995, Gastroenterology, 109, 2015, 10.1016/0016-5085(95)90771-8
Vidaud, 1996, Neurology, 46, 1485, 10.1212/WNL.46.5.1485
Shah, 1997, Am J Hum Genet, 61, 317, 10.1086/514864
Cossu, 1992, N Engl J Med, 327, 57, 10.1056/NEJM199207023270116
Loudianos, 1994, Prenat Diagn, 14, 999, 10.1002/pd.1970141018
Yamaguchi, 1999, Pediatr Int, 41, 405, 10.1046/j.1442-200x.1999.01096.x
Loudianos, 1999, Hum Mutat, 14, 294, 10.1002/(SICI)1098-1004(199910)14:4<294::AID-HUMU4>3.0.CO;2-9
Thomas, 1995, Am J Hum Genet, 56, 1140
Kim, 1998, Hum Mutat, 11, 275, 10.1002/(SICI)1098-1004(1998)11:4<275::AID-HUMU4>3.0.CO;2-L
Nanji, 1997, Am J Hum Genet, 60, 1423, 10.1086/515459
Wan, 2006, Biochem Biophys Res Commun, 345, 734, 10.1016/j.bbrc.2006.04.136
Margarit, 2005, Clin Genet, 68, 61, 10.1111/j.1399-0004.2005.00439.x
Deguti, 2004, Hum Mutat, 23, 398, 10.1002/humu.9227
Caca, 2001, J Hepatol, 35, 575, 10.1016/S0168-8278(01)00219-7
Firneisz, 2002, Am J Med Genet, 108, 23, 10.1002/ajmg.10220
Thomas, 1995, Nat Genet, 9, 210, 10.1038/ng0295-210
Palsson, 2001, Eur J Gastroenterol Hepatol, 13, 433, 10.1097/00042737-200104000-00023
Yener, 2004, J Gastroenterol Hepatol, 19, 114, 10.1111/j.1440-1746.2004.03254.x
Roche-Sicot, 1977, Ann Intern Med, 86, 301, 10.7326/0003-4819-86-3-301
Hamlyn, 1977, Br Med J, 2, 660, 10.1136/bmj.2.6088.660
McCullough, 1983, Gastroenterology, 84, 161, 10.1016/S0016-5085(83)80181-4
Rector, 1984, Liver, 4, 341, 10.1111/j.1600-0676.1984.tb00949.x
Enomoto, 1989, Jpn J Med, 28, 80, 10.2169/internalmedicine1962.28.80
Ferlan-Marolt, 1999, Dig Dis Sci, 44, 1054, 10.1023/A:1026637403894
Sallie, 1992, HEPATOLOGY, 16, 1206, 10.1002/hep.1840160517
Berman, 1991, Gastroenterology, 100, 1129, 10.1016/0016-5085(91)90294-U
Nazer, 1986, Gut, 27, 1377, 10.1136/gut.27.11.1377
Zandman-Goddard, 1994, J Clin Gastroenterol, 18, 265, 10.1097/00004836-199404000-00034
Sallie, 1994, Gut, 35, 849, 10.1136/gut.35.6.849
Lembowicz, 1999, Ultrastruct Pathol, 23, 39, 10.1080/019131299281824
Owada, 2002, J Pediatr, 140, 614, 10.1067/mpd.2002.122731
Aoki, 2003, Southeast Asian J Trop Med Public Health, 34, 80
Kroll, 2006, Mol Genet Metab, 89, 134, 10.1016/j.ymgme.2006.03.008
Sternlieb, 1968, N Engl J Med, 278, 352, 10.1056/NEJM196802152780702
Scheinberg, 1987, Lancet, 95, 10.1016/S0140-6736(87)92753-X
Siegel, 1977, J Biol Chem, 252, 254, 10.1016/S0021-9258(17)32825-9
Lipsky, 1978, J Immunol, 120, 1006, 10.4049/jimmunol.120.3.1006
Perrett, 1981, J Rheumatol, 7, 41
Wiesner, 1981, J Rheumatol, 8, 51
Bergstrom, 1981, Clin Pharmacol Ther, 30, 404, 10.1038/clpt.1981.180
Schuna, 1983, J Rheumatol, 10, 95
Kukovetz, 1983, J Rheumatol, 10, 90
Wei, 1970, Gastroenterology, 58, 288
Falkmer, 1970, Pediatrics, 45, 260, 10.1542/peds.45.2.260
Walshe, 1973, Q J Med, 42, 441
Sass-Kortsak, 1975, Pediatr Clin North Am, 22, 963, 10.1016/S0031-3955(16)33218-7
Grand, 1975, J Pediatr, 87, 1161, 10.1016/S0022-3476(75)80131-4
Sternlieb, 1980, Gastroenterology, 78, 1615, 10.1016/S0016-5085(19)30524-4
Czlonkowska, 1996, J Neurol, 243, 269, 10.1007/BF00868525
Brewer, 1987, Arch Neurol, 44, 490, 10.1001/archneur.1987.00520170020016
Walshe, 1993, Q J Med, 86, 197
Scheinberg, 1987, N Engl J Med, 317, 209, 10.1056/NEJM198707233170405
Becuwe, 2005, Dermatology, 210, 60, 10.1159/000081487
Deutscher, 1999, J Pediatr Gastroenterol Nutr, 29, 628, 10.1097/00005176-199911000-00031
Shiono, 2001, Am J Gastroenterol, 96, 3147, 10.1111/j.1572-0241.2001.05269.x
Walshe, 1982, Lancet, 1, 643, 10.1016/S0140-6736(82)92201-2
Walshe, 1986, Q J Med, 58, 81
Kodama, 1997, Life Sci, 61, 899, 10.1016/S0024-3205(97)00592-4
Sarkar, 1977, Proc R Soc Med, 70, 13
Borthwick, 1980, J Lab Clin Med, 95, 575
Walshe, 1979, Prog Clin Biol Res, 34, 271
Saito, 1991, Tohoku J Exp Med, 164, 29, 10.1620/tjem.164.29
Santos Silva, 1996, J Pediatr, 128, 285, 10.1016/S0022-3476(96)70412-2
Epstein, 1980, Gastroenterology, 78, 1442, 10.1016/S0016-5085(19)30498-6
Shiono, 2001, Med Electron Microsc, 34, 54, 10.1007/s007950100004
Hoogenraad, 1979, Eur Neurol, 18, 205, 10.1159/000115077
Hoogenraad, 1987, J Neurol Sci, 77, 137, 10.1016/0022-510X(87)90116-X
Brewer, 1987, Semin Neurol, 7, 209, 10.1055/s-2008-1041420
Brewer, 1983, Ann Intern Med, 99, 314, 10.7326/0003-4819-99-3-314
Cousins, 1985, Physiol Rev, 65, 238, 10.1152/physrev.1985.65.2.238
Hill, 1987, HEPATOLOGY, 7, 522, 10.1002/hep.1840070318
Schilsky, 1989, J Clin Invest, 84, 1562, 10.1172/JCI114333
Lang, 1993, Arch Neurol, 50, 1007, 10.1001/archneur.1993.00540100008005
Walshe, 1995, Arch Neurol, 52, 10, 10.1001/archneur.1995.00540250012003
Brewer, 1997, J Lab Clin Med, 129, 649, 10.1016/S0022-2143(97)90200-6
Alexiou, 1985, Arch Fr Pediatr, 42, 447
Marcellini, 2005, J Lab Clin Med, 145, 139, 10.1016/j.lab.2005.01.007
Lee, 2006, Clin Gastroenterol Hepatol, 4, 1069, 10.1016/j.cgh.2006.04.007
Brewer, 2001, J Lab Clin Med, 137, 191, 10.1067/mlc.2001.113037
Pecoud, 1975, Clin Pharmacol Ther, 17, 469, 10.1002/cpt1975174469
von Herbay, 1994, J Hepatol, 20, 41, 10.1016/S0168-8278(05)80465-9
Sokol, 1994, Gastroenterology, 107, 1788, 10.1016/0016-5085(94)90822-2
Ogihara, 1995, Pediatr Res, 37, 219, 10.1203/00006450-199502000-00016
Sinha, 2005, J Neurol Sci, 228, 121, 10.1016/j.jns.2004.10.017
Nagasaka, 2006, Pediatr Res, 60, 472, 10.1203/01.pdr.0000238341.12229.d3
Brewer, 1993, J Am Coll Nutr, 12, 527, 10.1080/07315724.1993.10718347
Ogra, 1998, J Inorg Biochem, 70, 49, 10.1016/S0162-0134(98)00012-9
Brewer, 2003, Arch Neurol, 60, 379, 10.1001/archneur.60.3.379
Brewer, 2006, Arch Neurol, 63, 521, 10.1001/archneur.63.4.521
Karunajeewa, 1998, Aust N Z J Med, 28, 215, 10.1111/j.1445-5994.1998.tb02975.x
Medici, 2006, Mov Disord, 21, 2030, 10.1002/mds.21109
Pan, 2002, Cancer Res, 62, 4854
Lowndes, 2004, Oncol Res, 14, 529, 10.3727/0965040042707952
Brewer, 2005, Curr Cancer Drug Targets, 5, 195, 10.2174/1568009053765807
Walshe, 1988, Lancet, 2, 435, 10.1016/S0140-6736(88)90423-0
Brewer, 1989, J Lab Clin Med, 114, 633
Arnon, 2007, J Pediatr Gastroenterol Nutr, 44, 596, 10.1097/MPG.0b013e3180467715
Walshe, 1986, Lancet, 1, 845, 10.1016/S0140-6736(86)90949-9
Askari, 2003, J Lab Clin Med, 142, 385, 10.1016/S0022-2143(03)00157-4
Sokol, 1985, J Pediatr, 107, 549, 10.1016/S0022-3476(85)80016-0
Petrasek, 2007, Liver Transpl, 13, 55, 10.1002/lt.20920
Jhang, 2007, J Clin Apher, 22, 10, 10.1002/jca.20118
Kiss, 1998, Transfusion, 38, 327, 10.1046/j.1537-2995.1998.38498257369.x
Rakela, 1988, Mayo Clin Proc, 63, 113, 10.1016/S0025-6196(12)64943-X
Rakela, 1986, Gastroenterology, 90, 2004, 10.1016/0016-5085(86)90274-X
Sarles, 1992, Eur J Pediatr, 151, 310, 10.1007/BF02072237
Kreymann, 1999, J Hepatol, 31, 1080, 10.1016/S0168-8278(99)80322-5
Stange, 1999, Artif Organs, 23, 319, 10.1046/j.1525-1594.1999.06122.x
Sen, 2002, Liver Transpl, 8, 962, 10.1053/jlts.2002.35546
Auth, 2005, J Pediatr Gastroenterol Nutr, 40, 54, 10.1097/00005176-200501000-00010
Shimono, 1991, Gastroenterol Jpn, 26, 69, 10.1007/BF02779512
Morimoto, 1986, Jpn J Med, 25, 59, 10.2169/internalmedicine1962.25.59
Dupont, 1990, Am J Obstet Gynecol, 163, 1527, 10.1016/0002-9378(90)90619-I
Soong, 1991, J Formos Med Assoc, 90, 693
Devesa, 1995, J Pediatr Gastroenterol Nutr, 20, 102, 10.1097/00005176-199501000-00018
Lao, 1988, Asia Oceania J Obstet Gynaecol, 14, 167, 10.1111/j.1447-0756.1988.tb00089.x
Brewer, 2000, HEPATOLOGY, 31, 364, 10.1002/hep.510310216
Endres, 1981, Klin Wochenschr, 59, 535, 10.1007/BF01716453
Biller, 1985, Eur Neurol, 24, 306, 10.1159/000115815
Hartard, 1994, Eur Neurol, 34, 337, 10.1159/000117074
Nunns, 1995, Eur J Obstet Gynecol Reprod Biol, 62, 141, 10.1016/0301-2115(95)02159-5
Sternlieb, 2000, HEPATOLOGY, 31, 531, 10.1002/hep.510310239
Groth, 1973, Transplant Proc, 5, 829
Eghtesad, 1999, Liver Transpl Surg, 5, 467, 10.1002/lt.500050614
Asonuma, 1999, Pediatr Transplant, 3, 201, 10.1034/j.1399-3046.1999.00014.x
Komatsu, 2002, Clin Transplant, 16, 227, 10.1034/j.1399-0012.2002.01074.x
Wang, 2005, Transpl Int, 18, 651, 10.1111/j.1432-2277.2004.00074.x
Tamura, 2005, Clin Transplant, 19, 483, 10.1111/j.1399-0012.2005.00371.x
Schumacher, 1997, Clin Transplant, 11, 217
Bax, 1998, Neurology, 51, 863, 10.1212/WNL.51.3.863
Lui, 1998, Transplant Proc, 30, 3324, 10.1016/S0041-1345(98)01048-3
Stracciari, 2000, Arch Neurol, 57, 384, 10.1001/archneur.57.3.384
Wu, 2000, Acta Neurol Scand, 102, 135, 10.1034/j.1600-0404.2000.102002135.x
Guarino, 1995, Acta Neurol Scand, 92, 405, 10.1111/j.1600-0404.1995.tb00155.x
Kassam, 1998, Can J Gastroenterol, 12, 65, 10.1155/1998/414236
Brewer, 2000, Liver Transpl, 6, 662, 10.1053/jlts.2000.18138
Senzolo, 2007, Clin Neurol Neurosurg, 109, 71, 10.1016/j.clineuro.2006.01.008
Medici, 2005, Liver Transpl, 11, 1056, 10.1002/lt.20486