NETosis: how vital is it?

Blood - Tập 122 - Trang 2784-2794 - 2013
Bryan G. Yipp1,2,3, Paul Kubes1,2,3,4
1Snyder Institute of Chronic Diseases, University of Calgary, Calgary, AB, Canada
2Department of Critical Care Medicine, Faculty of Medicine, University of Calgary, Calgary, AB, Canada
3The Immunology Research Group, University of Calgary, Calgary, AB, Canada
4Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada

Tóm tắt

AbstractIn this review, we examine the evidence that neutrophil extracellular traps (NETs) play a critical role in innate immunity. We summarize how NETs are formed in response to various stimuli and provide evidence that NETosis is not universally a cell death pathway. Here we describe at least 2 different mechanisms by which NETs are formed, including a suicide lytic NETosis and a live cell or vital NETosis. We also evaluate the evidence for NETs in catching and killing pathogens. Finally, we examine how infections are related to the development of autoimmune and vasculitic diseases through unintended but detrimental bystander damage resulting from NET release.

Tài liệu tham khảo

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